A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts

Holappa, Jukka; Nevalainen, Tapio; Safin, Rustam; Vepsäläinen, Jouko; Järvinen, Tomi

doi:10.1016/j.tetlet.2005.11.020

Cited by 3 publications

(2 citation statements)

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“…The 11‐ and 12‐methyl signals of diquaternary 8 are in different chemical shifts both in the 1 H and in 13 C spectra. This is the case also with the diquaternary 1‐carboxymethyl‐1,4,4‐trimethylpiperazi‐1,4‐dium diiodide 13…”

Section: Resultsmentioning

confidence: 78%

“…These organo‐soluble starting materials enable the modification reactions of chitosan in homogeneous solvent environments leading to high degrees of substitution, good control of the reaction and homogeneous placement of substituents along the backbone of chitosan. The preparation of quaternary piperazinium acetic acids is reported elsewhere 13. These quaternary piperazinium acids were coupled into chitosan with DCC and HOBt in NMP (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

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Novel Water‐Soluble Quaternary Piperazine Derivatives of Chitosan: Synthesis and Characterization

Holappa

Nevalainen

Safin

et al. 2006

Macromolecular Bioscience

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Novel synthesis methods for the preparation of quaternary piperazine derivatives of chitosan were developed. Quaternary ammonium moiety can be selectively inserted into either one or both of the piperazine nitrogens, yielding structurally uniform chitosan derivative structures. Water-soluble end products were thoroughly characterized with FT-IR, 1H NMR, 13C NMR and 2D 1H-13C HSQC NMR. The molecular weights of the end products were determined by GPC with triple detection.

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Section: Resultsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%