A Novel Animal Model of Parkinson’s Disease Using Optogenetics: Representation of Various Disease Stages by Modulating the Illumination Parameter

Lee, Eun Jung; Yoon, Hyun Soo; Park, Eun Suk; Min, Joongkee; Jeon, Sang Ryong

doi:10.1159/000486644

Cited by 10 publications

(6 citation statements)

References 48 publications

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“…The CRISPER/CAS9 technique was applied to monkeys to clarify the function of the PINK1 mutation [95]. Halorhodopsin was introduced into the SN of rats to mimic the various stages of PD [96]. Cutting-edge techniques such as CRISPER/CAS9 and optogenetics will advance PD research.…”

Section: Summary and Future Prospectivementioning

confidence: 99%

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

Kin

Yasuhara

Kameda

et al. 2019

IJMS

114

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Parkinson’s disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.

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Section: Summary and Future Prospectivementioning

confidence: 99%

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

Kin

Yasuhara

Kameda

et al. 2019

IJMS

114

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“…Interestingly, one study utilized advanced optogenetic manipulations to generate optogenetic models of PD representation of various disease stages (Lee et al., 2018) (Table 3). The PD optogenetic model not only shows characteristic PD manifestations, similar to those of the conventional models, but also was shown to present the advantage of representing various PD stages by controlling illumination parameters.…”

Section: Resultsmentioning

confidence: 99%

Optogenetics in chronic neurodegenerative diseases, controlling the brain with light: A systematic review

El Hajj,

Al Sagheer,

Ballout

2024

J of Neuroscience Research

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Neurodegenerative diseases are progressive disorders characterized by synaptic loss and neuronal death. Optogenetics combines optical and genetic methods to control the activity of specific cell types. The efficacy of this approach in neurodegenerative diseases has been investigated in many reviews, however, none of them tackled it systematically. Our study aimed to review systematically the findings of optogenetics and its potential applications in animal models of chronic neurodegenerative diseases and compare it with deep brain stimulation and designer receptors exclusively activated by designer drugs techniques. The search strategy was performed based on the PRISMA guidelines and the risk of bias was assessed following the Systematic Review Centre for Laboratory Animal Experimentation tool. A total of 247 articles were found, of which 53 were suitable for the qualitative analysis. Our data revealed that optogenetic manipulation of distinct neurons in the brain is efficient in rescuing memory impairment, alleviating neuroinflammation, and reducing plaque pathology in Alzheimer's disease. Similarly, this technique shows an advanced understanding of the contribution of various neurons involved in the basal ganglia pathways with Parkinson's disease motor symptoms and pathology. However, the optogenetic application using animal models of Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis was limited. Optogenetics is a promising technique that enhanced our knowledge in the research of neurodegenerative diseases and addressed potential therapeutic solutions for managing these diseases' symptoms and delaying their progression. Nevertheless, advanced investigations should be considered to improve optogenetic tools' efficacy and safety to pave the way for their translatability to the clinic.

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“…α-synuclein is hypothesised to contribute to toxicity and subsequent death of dopaminergic neurons in the substantia nigra pars compacta which is responsible for motor control [ 81 ]. To study the fixed stages of PD, an optogenetic PD model was constructed by introduction of the halorhodopsin (NpHR) gene, a light-gated chloride channel which inhibits neurons, into the substantia nigra compacta [ 82 ]. Unlike the classical animal model of PD, this novel optogenetic approach avoids causing damage to the nigrostriatal system and can be used as a PD model for various stages of the disease by adjustment of illumination parameters [ 82 ].…”

Section: Optogenetic Approachesmentioning

confidence: 99%

Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila

Lim

Kaur

Huang

et al. 2021

Cell. Mol. Life Sci.

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Many organs and tissues have an intrinsic ability to regenerate from a dedicated, tissue-specific stem cell pool. As organisms age, the process of self-regulation or homeostasis begins to slow down with fewer stem cells available for tissue repair. Tissues become more fragile and organs less efficient. This slowdown of homeostatic processes leads to the development of cellular and neurodegenerative diseases. In this review, we highlight the recent use and future potential of optogenetic approaches to study homeostasis. Optogenetics uses photosensitive molecules and genetic engineering to modulate cellular activity in vivo , allowing precise experiments with spatiotemporal control. We look at applications of this technology for understanding the mechanisms governing homeostasis and degeneration as applied to widely used model organisms, such as Drosophila melanogaster , where other common tools are less effective or unavailable.

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A Novel Animal Model of Parkinson’s Disease Using Optogenetics: Representation of Various Disease Stages by Modulating the Illumination Parameter

Cited by 10 publications

References 48 publications

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

Optogenetics in chronic neurodegenerative diseases, controlling the brain with light: A systematic review

Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila

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