2023
DOI: 10.21037/jtd-23-149
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A novel anoikis-related gene signature to predict the prognosis, immune infiltration, and therapeutic outcome of lung adenocarcinoma

Abstract: Background: Lung cancer is a highly aggressive disease and the leading cause of cancer-related deaths.Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. As a type of programmed cell death, anoikis serves a key role in tumor metastasis. However, as few studies have focused on anoikis and prognostic indicators in LUAD, in this study, we constructed an anoikis-related risk model to explore how anoikis could influence the tumor microenvironment (TME), clinical treatment, and prognos… Show more

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“…However, to accomplish eventual colonization in distant organs, the cells’ fate in circulation is particularly important. Anoikis is defined as the apoptosis that occurs when cells detach from the surrounding extracellular matrix (ECM) ( 11 - 14 ). After detaching from the primary lesions, the majority of tumor cells are eliminated through this process; however, a small subset of cancer cells reprogram intracellular and extracellular signals to survive in lymphatic and blood vessels ( 15 , 16 ).…”
Section: Introductionmentioning
confidence: 99%
“…However, to accomplish eventual colonization in distant organs, the cells’ fate in circulation is particularly important. Anoikis is defined as the apoptosis that occurs when cells detach from the surrounding extracellular matrix (ECM) ( 11 - 14 ). After detaching from the primary lesions, the majority of tumor cells are eliminated through this process; however, a small subset of cancer cells reprogram intracellular and extracellular signals to survive in lymphatic and blood vessels ( 15 , 16 ).…”
Section: Introductionmentioning
confidence: 99%