Kuitun city, Xinjiang is dry and short of water, so it is urgent to treat and utilize all kinds of unconventional water. In view of this problem, we conducted a study on the treatment of tiny pollution water in Kuitun River. We investigated the effect of dosage of powder activated carbon (PAC) on hollow-fiber ultrafiltration membrane (HUM) performance. The results show that the stable operation time of hollow fiber ultrafiltration membranes lengthened and the rate of reduction of the flux was reduced when the PAC dosage was increased. The addition of PAC had no obvious effect on the resistance of membrane filtration. We conducted experiments to evaluate the effect of ultrafiltration of tiny pollution water in combination with PAC. When the parameters of operation and PAC dosage were appropriately regulated, the removal rates of chemical oxygen demand (COD), ammonia nitrogen (NH3-N) and ferric ions (Fe) reached 62%, 32% and 90%, respectively. When the PAC dosage was 200 mg/L, 100 mg/L and 150 mg/L, the highest removal rates were achieved under normal temperature and pressure. The effluent COD was less than 5.0 mg/L, NH3-N was less than 1.5 mg/L and Fe was less than 0.5 mg/L, achieving better results than the quality standard of surface water (GB3838-2002). The treated water can be discharged into the river or recirculated to utilities. The fouled membrane was cleaned by water rinsing, water/acid rinsing and water/alkali rinsing, with recovery ratios of 44%, 81% and 88%, respectively. The results of this study can serve as a foundation for the efficient utilization of water resources and the development of new water treatment technologies in Xinjiang.