A novel antioxidant sulfated polysaccharide from the algae Gracilaria caudata: In vitro and in vivo activities

Alencar, Poliana O. Cavalcante; Lima, Glauber Cruz; Barros, Francisco Clark Nogueira; Costa, Luís Eduardo Castanheira; Ribeiro, Carla Vivianne P.E.; Sousa, Willer Malta de; Sombra, Venícios Gonçalves; Abreu, Clara M.W.S.; Abreu, Ewerton Sousa de; Pontes, Edivânia Oliveira Bezerra; Oliveira, Ariclécio Cunha de; Paula, Regina C.M. de; Freitas, Ana Lúcia Ponte

doi:10.1016/j.foodhyd.2018.12.007

Cited by 74 publications

(22 citation statements)

References 61 publications

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“…Polysaccharides from Fuzhuan brick teas displayed good free radical scavenging activity in vitro and also had protective effects on high-fat diet-induced oxidative injury in vivo [36]. Polysaccharides from the algae Gracilaria caudata exhibited significant antioxidant activity in vitro and also greatly improved the antioxidant system in rats [37]. Oxidative stress is produced under diabetic conditions in various tissues and damages cellular organelles, which increases lipid peroxidation and causes insulin resistance [38].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

et al. 2019

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Guava (Psidium guajava L., Myrtaceae) leaves have been used as a folk herbal tea to treat diabetes for a long time in Asia and North America. In this study, we isolated polysaccharides from guava leaves (GLP), and evaluated its antioxidant activity in vitro and anti-diabetic effects on diabetic mice induced by streptozotocin combined with high-fat diet. The results indicated that GLP exhibited good DPPH, OH, and ABTS free-radical scavenging abilities, and significantly lowered fasting blood sugar, total cholesterol, total triglycerides, glycated serum protein, creatinine, and malonaldehyde. Meanwhile, it significantly increased the total antioxidant activity and superoxide dismutase (SOD) enzyme activity in diabetic mice, as well as ameliorated the damage of liver, kidney, and pancreas. Thus, polysaccharides from guava leaves could be explored as a potential antioxidant or anti-diabetic agents for functional foods or complementary medicine.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

et al. 2019

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“…For the biodegradation product (Figure 4D), the peaks at around 100, 76, 73, 70, and 62 ppm might relate to C1, C3, C2, C4, and C6, respectively [27]. From the dept 135 13 C NMR spectra of the biodegradation product (Figure 4E), peaks at around 61 ppm and 63 ppm might relate to CH 2 , and these singles in the opposite amplitude were possibly corresponding to CH in this biodegradation product [28,29]. The results of monosaccharide composition and FT-IR analyses indicated that the biodegradation product could almost be confirmed as xanthan gum.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Antioxidant Activity of a Low-Molecular-Weight Xanthan Gum

Wang

et al. 2019

Biomolecules

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In the present work, a low-molecular-weight xanthan gum (LW-XG) was successfully obtained via biodegradation of commercial xanthan by the endophytic fungus Chaetomium globosum CGMCC 6882. The monosaccharide composition of LW-XG was glucose, mannose, and glucuronic acid in a molar ratio of 1.63:1.5:1.0. The molecular weight of LW-XG was 4.07 × 104 Da and much smaller than that of commercial xanthan (2.95 × 106 Da). Antioxidant assays showed that LW-XG had a good scavenging ability on DPPH radicals, superoxide anions, and hydroxyl radicals and good ferric reducing power. Moreover, LW-XG exhibited excellent protective effect on H2O2-injured Caco-2 cells. Results of this work suggested that LW-XG could be used in foods or pharmaceuticals to alleviate and resist the oxidative damage induced by the overproduction of reactive oxygen species.

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“…Algae produce various secondary metabolites with many antioxidant activities such as pigments (phycobiliproteins, chlorophylls and carotenoids), polyphenols (bromophenols, flavonoids, phlorotannins and phenolic acids), vitamins (β-carotene and other carotenoids), a complex of B vitamins (B1, B2, B3, B5, B6, B7 and B12), vitamin C (ascorbic acid), vitamin D and vitamin E (α-tocopherol) [40,41]. Sulfated polysaccharides are nonanimal compounds reported to have antioxidant activities, which can be obtained from marine algae and other marine organisms from the phaeophyta group [42]. These compounds may be used as hydrocolloids and as nutraceuticals in the food industry.…”

Section: Natural Sources Of Antioxidantsmentioning

confidence: 99%

Valorization of Natural Antioxidants for Nutritional and Health Applications

Ferreira-Santos¹,

Genisheva²,

Botelho³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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The significant increase in the world population age, 47 years in 1950 to 73 years in 2020, resulted in an increase in aging related diseases as well as in degenerative diseases. In consequence, researchers have been focusing in the development of new therapies, with a particular emphasis on the use of compounds with antioxidant properties, namely phytochemicals, such as polyphenols and carotenoids. Several in vitro and in vivo studies have demonstrated the phytochemicals antioxidant capacity. Their use is broad, as they can be part of food supplements, medicine and cosmetics. The health benefit of antioxidant phytochemicals is an indisputable question. Phytochemical properties are highly influenced by the natural matrix as well as by extraction process, which have a key role. There are several extraction methods that can be applied depending on the chemical properties of the bioactive compounds. There is a wide range of solvents with different polarities, which allows a selective extraction of the desired target family of compounds. Greener technologies have the advantage to reduce extraction time and solvent quantity in comparison to the most traditional methods. This chapter will focus on the different green extraction strategies related to the recovery of antioxidant bioactive compounds from natural sources, their nutritional and health potential.

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A novel antioxidant sulfated polysaccharide from the algae Gracilaria caudata: In vitro and in vivo activities

Cited by 74 publications

References 61 publications

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves

Characterization and Antioxidant Activity of a Low-Molecular-Weight Xanthan Gum

Valorization of Natural Antioxidants for Nutritional and Health Applications

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