A novel application of the T-cell for flow-through dissolution: The case of bioceramics used as ibuprofen carrier

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

“…Indeed, several methods described in the literature try to simulate in vivo conditions and to avoid non-physiological turbulence. In most cases, loaded scaffolds are soaked in a beaker, a bottle or a sampling tube and/or in a culture chamber with or without controlled agitation (Guicheux et al 1997;Paul & Sharma 1999;Krajewski et al 2000;Perry et al 2002;Hasegawa et al 2004;Murugan & Ramakrishna 2004;Palazzo et al 2005;Medvecky et al 2007;Melville et al 2008;Victor & Kumar 2008;Chevalier et al 2009). Released tests are usually performed considering only low volumes (from 3 up to 150 ml) of various dissolution media (phosphate buffer, saline physiological solution, SBF, etc.).…”

“…) (Perry et al 2002;Hall et al 2004;Chevalier et al 2009). Moreover, it could be beneficial to mimic the blood/plasma flow speed observed at the site of the scaffold's implantation (Baroli 2009).…”

β-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions

“…Porous β-TCP pellets were fabricated by wet high-shear granulation followed by spheronization in a Mi-Pro high-shear granulator (Pro-C-epT, Zelzate, Belgium) as described in previous works [18,19]. Tricalcium phosphate powder (Ca 3 (PO 4 ) 2 , Cooper, France) and pregelatinized starch (Sepistab ST 200, Seppic, France) were used as granule skeleton and binder/pore former, respectively.…”

“…Such drug delivery system can also be used for the local treatment of articular inflammatory pathologies such as arthritis. In previous studies [18][19][20][21][22], porous β-TCP pellets were produced by high-shear wet granulation and loaded with ibuprofen by solvent evaporation method. The spherical form and the size of these implants, 900 µm in diameter, can guarantee the filling of complex-shaped bone cavities, while maintaining intergranular spaces of about 180 µm for bone ingrowth.…”

“…β-TCP porous pellets were fabricated by wet high shear granulation as in previous works [18][19][20][21][22]. The obtained pellets were loaded through impregnation: they were soaked in ibuprofen solutions, separated from their supernatant and then dried under ambient conditions.…”