A novel approach for noninvasive drug delivery and sensing through the amniotic sac

Azagury, Aharon; Amar-Lewis, Eliz; Mann, Ella; Goldbart, Riki; Traitel, Tamar; Jelinek, Raz; Hallak, Mordechai; Kost, Joseph

doi:10.1016/j.jconrel.2014.03.040

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…Therefore, polymeric NPs with different properties (bioadhesive, biodegradable, and biocompatible) were manufactured using the PIN method. [ 42 ] The size and surface charge of these NPs were measured in DI water and 0.1% mucin solution ( Figures and , respectively).…”

Section: Resultsmentioning

confidence: 99%

“…[40] The protocol for sample preparation was developed based on the suggestion in Baker et al [41] This approach has been used before for the detection and quantification of specific components in biological specimens such as the skin, liver, release of Nigella sativa oil, and chorioamnion membrane. [42][43][44][45] Our customized FTIR method is practical, efficient, cost-effective, and available to many labs. The method was initially utilized to quantify PS NP content in exposed GI tissue.…”

Section: The Absorption Of Ps Nps In Gi Tissue By Temmentioning

confidence: 99%

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Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Azagury

Baptista

Milovanovic

et al. 2022

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Decades of research into the topic of oral nanoparticle (NP) delivery has still not provided a clear consensus regarding which properties produce an effective oral drug delivery system. The surface properties—charge and bioadhesiveness—as well as in vitro and in vivo correlation seem to generate the greatest number of disagreements within the field. Herein, a mechanism underlying the in vivo behavior of NPs is proposed, which bridges the gaps between these disagreements. The mechanism relies on the idea of biocoating—the coating of NPs with mucus—which alters their surface properties, and ultimately their systemic uptake. Utilizing this mechanism, several coated NPs are tested in vitro, ex vivo, and in vivo, and biocoating is found to affect NPs size, zeta‐potential, mucosal diffusion coefficient, the extent of aggregation, and in vivo/in vitro/ex vivo correlation. Based on these results, low molecular weight polylactic acid exhibits a 21‐fold increase in mucosal diffusion coefficient after precoating as compared to uncoated particles, as well as 20% less aggregation, and about 30% uptake to the blood in vivo. These discoveries suggest that biocoating reduces negative NP charge which results in an enhanced mucosal diffusion rate, increased gastrointestinal retention time, and high systemic uptake.

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Section: Resultsmentioning

confidence: 99%

Section: The Absorption Of Ps Nps In Gi Tissue By Temmentioning

confidence: 99%

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Azagury

Baptista

Milovanovic

et al. 2022

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“…Invasive procedures have mainly been used for prenatal diagnostic tests, such as amniocentesis and chorionic villus sampling, but principles can be extrapolated for targeted drug delivery as well. 457 For example, a study by Ellah and colleagues reported IGF-1 plasmid DNA loaded polymeric NPs with effective and trophoblast specific transgene expression after direct murine placental injection. 458 Fetal targeting can be invasively enhanced, for example by intra-amniotic administration of PAMAM dendrimer-based therapeutics.…”

Section: Box 4: Placental Barrier Characteristicsmentioning

confidence: 99%

Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

et al. 2023

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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A novel approach for noninvasive drug delivery and sensing through the amniotic sac

Cited by 11 publications

References 24 publications

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

Drug Delivery Systems

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