2015
DOI: 10.1007/s12010-015-1696-x
|View full text |Cite
|
Sign up to set email alerts
|

A Novel Approach for Overcoming Drug Resistance in Breast Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 (ALDH1A1) and Glycogen Synthase Kinase-3 β (GSK-3β)

Abstract: Breast cancer stem cells are well known to resist the traditional methods like chemo and radio therapy. Aldehyde dehydrogenase 1 (ALDHIA1) and glycogen synthase kinase-3 β (GSK-3β) are the two selected proteins for study, due to their overexpression and upregulation in breast cancer cells. Curcumin, the yellow pigment of the spice turmeric, is widely reported as an antioxidant and acts as a synergist along with traditional drugs. Under hypoxic conditions, it gets converted to free radical which causes apoptosi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
18
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 45 publications
(18 citation statements)
references
References 42 publications
0
18
0
Order By: Relevance
“…Aldehyde dehydrogenase (ALDH) has been described as a marker of both normal and malignant breast stem/progenitor cells ( Ginestier et al, 2007 ; Ricardo et al, 2011 ). ALDH converts retinol to retinoic acid, and is a putative enzyme having important properties in differentiation pathways in normal as well as cancer stem cells ( Lohberger et al, 2012 ; Kesharwani et al, 2015 ). ALDH overexpression has been correlated with increased tumorigenesis in comparison to CD 44 + cells alone, indicating ALDH as a specific marker of BCSCs in breast cancers ( Vira et al, 2012 ).…”
Section: Bcscs Theorymentioning
confidence: 99%
“…Aldehyde dehydrogenase (ALDH) has been described as a marker of both normal and malignant breast stem/progenitor cells ( Ginestier et al, 2007 ; Ricardo et al, 2011 ). ALDH converts retinol to retinoic acid, and is a putative enzyme having important properties in differentiation pathways in normal as well as cancer stem cells ( Lohberger et al, 2012 ; Kesharwani et al, 2015 ). ALDH overexpression has been correlated with increased tumorigenesis in comparison to CD 44 + cells alone, indicating ALDH as a specific marker of BCSCs in breast cancers ( Vira et al, 2012 ).…”
Section: Bcscs Theorymentioning
confidence: 99%
“…Quan et al reported that hyaluronan (HA) is a specific ligand for CD44, and HA-conjugated cisplatin which targets CD44 has highly selective and sensitive anticancer effects in NSCLC cells (33). The novel synthetic curcumin analogues against ALDH1A1 and GSK-3β have functions to overcome chemoresistance in breast cancer (34). Based on induction of the stem-like feature in lung cancer cells by cisplatin treatment, we also observed Notch3, CD44 and ALDH1A1 expression levels were upregulated in the A549 and H520 cells with cisplatin treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, its main delivery problem lies in its extreme poor aqueous solubility. Currently, BDMC is under extensive research to enhance its targeted delivery to malignant or diseased sites and improve its poor aqueous solubility …”
Section: Introductionmentioning
confidence: 99%
“…Currently, BDMC is under extensive research to enhance its targeted delivery to malignant or diseased sites and improve its poor aqueous solubility. [21][22][23] Accordingly, the goal of the current study was devoted to formulate biodegradable BDMC-loaded PLGA NPs with high entrapment potential and small particle size aiming for the efficient passive targeting of solid tumors and the minimized untoward adverse effects occurring in the normal tissues. Moreover, to increase the systemic half-life and the therapeutic efficiency, the effect of some coating moieties on the surface hydrophilicity, particle size, zeta potential and in-vitro cytotoxicity of a selected formulation were investigated.…”
Section: Introductionmentioning
confidence: 99%