A novel approach in pharmaceutical analysis by laser induced breakdown spectroscopy combined with chemometric methods and artificial neural network

Abstract

As a reliable method, Laser induced breakdown spectroscopy (LIBS) is widely applied to elemental analysis in different fields. In this research, LIBS was used to analyze pharmaceutical tablets. For this purpose, spectra from eight samples of three pharmaceutical classes were acquired; and after peaks recognition, they were investigated by principal component analysis (PCA) and artificial neural network (ANN). According to the results, due to the similarity of the main elements of different samples, it is difficult to distinguish them by spectra; therefore, PCA was used to make a better comparison between the samples. Apart from that, unknown samples were identified and predicted through the ANN.

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

“…These interferences included but were not limited to 35 Cl 16 O + , 40 Ar 16 OH + , 38 Ar 18 OH + , 70 GeH + , 40 Ar 35 Cl + , 73 Ge 16 O + and 74 Ge 16 O + which would normally interfere with 51 V + , 57 Fe + . 57 Fe + , 71 Ga + , 75 As + , 89 Y + and 90 Zr + , respectively. Analyte LOD were in the range 0.05-and by comparing the results obtained using their methodology with those obtained using direct current arc optical emission spectrometry.…”

“…The second paper, by Farhadian et al , again used PCA and ANN on LIBS data obtained from eight samples of three pharmaceutical classes (statins, beta blockers and benzodiazepines). 71 Using a commercial instrument, they analysed the same spot on each sample 10 times and then measured the same sample in 10 different places. Each sample was therefore analysed a total of 100 times.…”

“…The superior resolving power of the Orbitrap system managed to separate polyatomic interferences that even the "high" resolution TOF-MS systems could not, e.g. the 71 GaO could easily be separated from the 75 AsC peaks. This higher resolving power can potentially be put to good use for detecting impurities or implants in these nano-sized objects.…”