A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles

Idoudi, Sourour; Bedhiafi, Takwa; Korashy, Hesham M.; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru

doi:10.1016/j.carbpol.2022.120034

Cited by 17 publications

(4 citation statements)

References 40 publications

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“…ChNPs have very good anticancer properties, which have been confirmed by many researchers [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. They have been proven to be toxic to oral cavity [ 28 ], breast [ 29 , 30 , 31 , 32 ], prostate [ 33 , 34 ], glioblastoma [ 35 ], liver [ 36 , 37 ], and colon cancers [ 37 , 38 ], while showing satisfactory biocompatibility with normal developing cells and/or tissues. The main assessment of the anti-cancer effect of the newly formed NPs, apart from the release kinetics, was to obtain a dependence of the release on pH conditions, which is very beneficial in targeted therapy [ 39 ].…”

Section: Introductionmentioning

confidence: 76%

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

et al. 2023

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Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan’s properties in drug delivery systems (DDS), as well as the method of NPs production was quoted. Additionally, the specification and classification of the NPs’ morphological features determined their application together with the methods of attaching drugs to NPs. The latest scientific reports of the DDS using ChNPs administered orally, through the eye, on the skin and transdermally were taken into account.

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Section: Introductionmentioning

confidence: 76%

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

et al. 2023

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“…These findings suggested that TSP can enhance the encapsulation effect of zein on curcumin, which was possibly due to the porous and loose structure of the zein and TSP complex, allowing for better embedding of curcumin. 32,33 Other studies have also reported that protein–polysaccharide complexes improved the encapsulation efficiency and loading capacity of curcumin, such as zein– Tremella polysaccharide, 34 zein–xanthan gum, 35 casein–soy polysaccharide, 21 and Mesona chinensis polysaccharide–chitosan polyelectrolyte composite hydrogels. 36…”

Section: Resultsmentioning

confidence: 98%

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Xie,

Zhu,

Zeng

et al. 2024

Food Funct.

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“…Curcumin diethyl dissucinate has better stability in physiological conditions and higher antitumor activity than curcumin, but is also poorly water-soluble. Thus succinylated-CUR was successfully encapsulated in mannose-modified chitosan, as mannose receptors are highly expressed in cancer cells [ 93 ]. Another nanocarrier for oral drug administration was composed of chitosan–alginate NPs [ 94 ].…”

Section: Cs Np Platforms For a Specific Drug Deliverymentioning

confidence: 99%

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Kurczewska

2023

Pharmaceutics

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Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery systems of different active agents. Recently, much attention has been paid to nanodelivery systems as carriers to enable better bioavailability, and thus higher efficiency of the loaded drug. The present review is focused on the progress in chitosan-based nanoparticles for the targeted delivery of antitumor drugs. The paper discusses literature reports from the last three years in which chitosan nanoparticles were applied as carriers for active substances used in antitumor therapy and potential new drugs with anticancer properties. Special attention was paid to the different treatments applied to increase the therapeutic effectiveness and minimize the side effects of a specific active substance.

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A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles

Cited by 17 publications

References 40 publications

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

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