A Novel Approach to Assessing Changes in Prostate Stiffness With Age Using Virtual Touch Tissue Quantification

Zheng, Xiao‐Zhi; Ji, Ping; Mao, Hongwei; Zhang, Mengjie; Xia, Enhui; Xing-Gu,; Chen, Xuefeng

doi:10.7863/jum.2011.30.3.387

Cited by 28 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Virtual touch tissue quantification (VTTQ) is a promising new implementation of acoustic radiation force impulse ultrasound imaging, which provides numerical measurements [shear wave velocity (SWV) values] of tissue stiffness. Up to date, VTTQ has been widely used to evaluate the stiffness of superficial and deep tissues in adults, such as the thyroid gland [2,3], breast [4,5], liver [6][7][8][9], kidneys [6,10], prostate [11,12], and other organs [6]. However, there are only two publications on the topic involving placental stiffness [13,14] and the application of VTTQ in fetuses has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

Zheng

Tan

2016

Med Ultrason

Self Cite

View full text Add to dashboard Cite

Aims: Virtual touch tissue quantification (VTTQ) has been widely used in adults, but its application in fetuses has not been reported. The purposes of this study were to describe the normal shear wave velocity (SWV) values of fetal brain, lung, and liver by VTTQ and to examine the clinical usefulness of this procedure in evaluation of gestational age-related SWV changes in the fetal brain, lung and liver. Material and methods: One hundred fetuses were enrolled in this study and were evaluated at 18 weeks (second trimester) and 35 weeks (third trimester) during pregnancy. The SWV was measured at the cerebral parenchyma, thalamus, cerebellum, choroid plexus, left lung, right lung, right and left lobe of the liver in each participant. Results: The SWV at the cerebral parenchyma were all significantly greater in the third trimesters than in the second trimesters (3.29±1.05 vs. 2.22±0.97 m/s, p<0.001), while the velocities at thalamus, cerebellum, choroid plexus, left lung, right lung, right lobe of the liver and left lobe of the liver did not differ between the second and the third trimesters (p>0.05). Moreover, the SWV at the cerebral parenchyma correlated significantly with gestational age (r=0.47, p<0.001). Conclusions: VTTQ can provide numerical measurements of fetal brain, lung and liver stiffness and can effectively and objectively indicate gestational age-related changes in cerebral parenchyma stiffness by measuring SWV values.Keywords: fetal tissues, stiffness, gestational age, shear wave velocity, virtual touch tissue quantification A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

show abstract

Section: Introductionmentioning

confidence: 99%

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

Zheng

Tan

2016

Med Ultrason

Self Cite

View full text Add to dashboard Cite

show abstract

“…Then VTTQ was performed with the preliminary identification of a target region of interest (ROI) (box with fixed dimension of 1 × 0.5 cm) on a conventional US image. Finally, an acoustic push pulse was transmitted immediately on the right side of the ROI where the SWVs were calculated and expressed with a numerical value (m/s) as a result of multiple measurements made for the same spatial location (9-11). …”

Section: Methodsmentioning

confidence: 99%

Preliminary Study on the Kidney Elasticity Quantification in Patients With Chronic Kidney Disease Using Virtual Touch Tissue Quantification

Xiao¹,

Yang²,

Fu³

2014

Iran J Radiol

View full text Add to dashboard Cite

Background:Virtual touch tissue quantification (VTTQ) provides numerical measurements (shear wave velocity (SWV) values) of tissue stiffness.Objectives:The purpose of this study was to describe the SWV values of the kidney by VTTQ and to examine the clinical usefulness of this procedure in the evaluation of elasticity changes in the kidneys of patients with chronic kidney disease (CKD).Patients and Methods:Sixty-five patients with CKD and seventy healthy participants were included in this study. A total of 270 kidneys were examined by VTTQ. The kidney elasticity was expressed as shear wave velocity. The SWV values, blood serum creatinine (Scr)/BUN and pathological findings were analyzed and compared between patients with CKD and healthy participants.Results:In patients with CKD and healthy participants, the SWV values both gradually decreased from the renal cortex to the medulla and renal sinus The SWV value of the renal cortex in patients with CKD was less than that of healthy participants (P < 0.05), and the SWV value of the renal cortex in patients with renal insufficiency was significantly less than in those with normal renal function (2.46 ± 0.15 vs. 3.45 ± 0.26 m/s, P < 0.05). The best cutoff value for predicting renal insufficiency (Scr > 1.24 mg/dL or/and BUN > 21 mg/DL) was a SWV value of the renal cortex of less than 1.92 m/s with a sensitivity of 84.4% (95% CI: 67.2-94.7%) and a specificity of 96.8% (95% CI: 83.3-99.9%) (P < 0.001).Conclusion:VTTQ can sensitively detect the elasticity changes in patients with CKD, and it can effectively predict renal insufficiency. This technology provides a valuable tool for the assessment of CKD.

show abstract

“…Ultrasound elastography (strain or shear wave type) has been widely used in the clinical setting for the diagnosis of benign and malignant tumors in the thyroid [1,2], breast [3,4], liver [5][6][7][8], kidney [9], prostate [10,11] and lymph nodes [12,13], for guiding and monitoring the interventional diagnosis and treatment [14,15], and even for the assessment of the placenta [16,17] and fetal maturity [18]. In ophthalmology the mechanical properties of cornea [19], lens [20], and eye [21,22] have also been studied using elastography.…”

Section: Introductionmentioning

confidence: 99%

The safety and feasibility of diagnostic acoustic radiation force impulse elastography used for eyes. A preliminary in vivo study

et al. 2017

View full text Add to dashboard Cite

Aims: To assess the safety and feasibility of acoustic radiation force impulse (ARFI) elastography in the eyes of rats. Material and methods: One hundred and twenty-six SD rats were divided into 7 groups. Group 1 was the control group and Group 2 to Group 7 were investigated by ARFI elastography using increased powers of 5%, 10%, 20%, 50%, and 100% and repetitions of 5 or 10. The changes of ocular architecture structures and functions were examined by phthalmoscopic, histopathologic, and light reflex examination, and the expression level of IL-6, IL-8, and TNF-α was determined in days 1, 3, and 7 after ARFI elastography, respectively.Results: A satisfactory ARFI elastography was obtained in all SD rats. The shear wave velocity (SWV) values of soft tissues behind the eyeball were significantly greater than those of the eyes (1.89±0.95 vs. 0.84±0.36 m/s, p<0.05). The SWV values of eyes and the soft tissues behind the eyeball did not differ among any groups at any time-point (p>0.05). The SD rats of each group showed good light perception, pupillary light reflex, and avoidance reaction induced by the sudden bright light from the dark environment at any time. In each group, ocular architecture structures were well preserved, and with a normal expression level of IL-6, IL-8, and TNF-α (p>0.05).Conclusions: Diagnostic ARFI elastography is a safe and feasible ultrasonic imaging mode and may potentially be applied for human eyes in its present form.

show abstract

A Novel Approach to Assessing Changes in Prostate Stiffness With Age Using Virtual Touch Tissue Quantification

Abstract: Virtual touch tissue quantification can provide numerical measurements of prostate stiffness and can effectively and objectively indicate age-related changes in prostate stiffness by measuring shear wave velocity values.

Cited by 28 publications

References 19 publications

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

Preliminary Study on the Kidney Elasticity Quantification in Patients With Chronic Kidney Disease Using Virtual Touch Tissue Quantification

The safety and feasibility of diagnostic acoustic radiation force impulse elastography used for eyes. A preliminary in vivo study

Contact Info

Product

Resources

About