2017
DOI: 10.3892/ol.2017.7684
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A novel approach to glioma therapy using an oncolytic adenovirus with two specific promoters

Abstract: Abstract. Gliomas are the most common type of primary brain tumor in adults, where more than half of the cases are malignant, and the prognosis is poor. The early viral 1A (E1A) protein has been widely recognized to be essential for adenoviral replication and production of progeny virions in human cells, a process that is regulated by human telomerase reverse transcriptase. The p53 gene, as a tumor suppressor, regulates diverse cellular processes, including cell cycle arrest, cell autophagy, senescence and apo… Show more

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Cited by 10 publications
(11 citation statements)
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“…Tumour-specific promotors can control the expression of viral genes or therapeutic genes to select replication in tumour cells instead of normal cells. 9,10 The cell surface protein, carbonic anhydrase IX (CAIX), is a tumour-sassociated antigen of renal cancer. 11 CAIX expression is almost not detected on normal kidney cells or other normal cells, but an increasing expression is detected on 90% of renal cancer lesions.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Tumour-specific promotors can control the expression of viral genes or therapeutic genes to select replication in tumour cells instead of normal cells. 9,10 The cell surface protein, carbonic anhydrase IX (CAIX), is a tumour-sassociated antigen of renal cancer. 11 CAIX expression is almost not detected on normal kidney cells or other normal cells, but an increasing expression is detected on 90% of renal cancer lesions.…”
Section: Introductionmentioning
confidence: 99%
“…Tumour‐specific promotors can control the expression of viral genes or therapeutic genes to select replication in tumour cells instead of normal cells 9,10 . The cell surface protein, carbonic anhydrase IX (CAIX), is a tumour‐sassociated antigen of renal cancer 11 .…”
Section: Introductionmentioning
confidence: 99%
“…Based on these data, cancer can be considered as a significant public health issue worldwide, and thus requires intense research into the improvement of prevention strategies and enhancing the effectiveness of treatment. Numerous types of curative therapy, including chemotherapy (4), gene therapy (5), radiotherapy and immunotherapy (6,7), are used to treat cancer. Radiotherapy is an effective and commonly employed treatment in the management of >50% of human malignancies and remains a standard therapeutic modality for cancer patients (8,9).…”
Section: Introductionmentioning
confidence: 99%
“…Based on the data enumerated above, cancer can be considered as an important public health which needs the strong strategies of management for its prevention and its treatment. Moreover, many kinds of strategies of treatment such as chemotherapy [ 2 ], immunotherapy [ 3 ], genetherapy [ 4 ], nanotherapy [ 5 ], radiotherapy [ 6 ], phytotherapy [ 7 ] have been developed and used to treat cancer. Among all strategies mentioned above, Radiotherapy seems more important because, in many countries, more than 50% of new cases of cancer received at least one course of radiotherapy during their lifetime [ 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%