“…The interventions used in the studies included oral care [ 22 ], saliva substitutes [ 22 , 24 , 25 ], and various approaches to stimulate saliva secretion (i.e., acupuncture [ 23 , 26 ], ice cubes [ 30 ], toothpicks [ 27 ], and pilocarpine [ 21 ]). Of the 11 studies, seven were randomized controlled trials [ 20 , 21 , 24 , 25 , 28 - 30 ], and four were non-randomized trials [ 22 , 23 , 26 , 27 ]. Three of the seven randomized trials were double-blind [ 21 , 24 , 28 ], and five of the 11 trials were crossover studies [ 20 , 21 , 25 , 28 , 30 ].…”