A Novel Approach to Treatment With High-Dose Steroid as a Differentiation Inducer in Children With Acute Myeloblastic Leukemia

Hiçsönmez, G

doi:10.1080/15227950050147426

Cited by 3 publications

(1 citation statement)

References 13 publications

(21 reference statements)

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“…We used the St. Jude ALL TXIII remission induction protocol for ALL patients, whereas LMB/LMT 89 chemotherapy protocol was utilized for NHL patients [6,7]. AML patients received chemotherapy regimen according to our institutional chemotherapy protocol [8].…”

Section: Resultsmentioning

confidence: 99%

Varicella infection with childhood hematological malignancy: A single institution experience of 27 cases

Bay

Öner

Doğan

et al. 2015

J Pediatr Infect Dis

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Varicella remains a dangerous viral pathogen for pediatric cancer patients. The incidence of primary varicella infection in Eastern of Turkiye is still high because of low vaccination rate. Medical records of 27 pediatric patients with hematological malignancies that developed varicella/herpes zoster were retrospectively reviewed. All were treated at a single medical center in Eastern Turkiye between 1997 and 2006. Varicella (n = 22) or herpes zoster (n = 5) were diagnosed in 27 cases, of whom 14 had acute lymphoblastic leukemia (ALL), five had acute myeloblastic leukemia (AML), and eight had non-Hodgkin lymphoma (NHL). The mean age of the children was 5.7 ? 3.2 years. None of these children had evidence of disseminated disease. The mean total leukocyte count was 2600 ? 1500/mm3 in ALL group, 2300 ? 1800/mm3 in AML group, and 3100 ? 1700/mm3 in NHL group. While intravenous acyclovir was administered to 21 patients, remaining six patients were received oral acyclovir. Fever was reduced in mean 5.6 ? 2.1, 5.2 ? 1.7 and 4.4 ? 1.8 days in ALL, AML, and NHL groups, respectively. None of the 27 children worsened or developed features of visceral dissemination. Outcome of the patients were not different in terms of oral and intravenous acyclovir use. These results suggest that in our institution varicella is not associated with a high incidence of mortality in cancer patients. Early administration of acyclovir can prevent the visceral dissemination of varicella-zoster virus. Prednisolone usage during the incubation period of varicella did not result in increased severe varicella infection.

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Section: Resultsmentioning

confidence: 99%

Varicella infection with childhood hematological malignancy: A single institution experience of 27 cases

Bay

Öner

Doğan

et al. 2015

J Pediatr Infect Dis

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Myeloprotective effect of short‐course high‐dose methylprednisolone treatment before consolidation therapy in children with acute myeloblastic leukemia

Elmas¹,

Çetin²,

Tuncer³

et al. 2005

American J Hematol

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In our previous studies, short-course high-dose methylprednisolone (HDMP) has been shown to shorten the chemotherapy-induced neutropenic period by stimulating the CD34 + hematopoietic progenitor cells in children with acute leukemia. In this study, we investigate the role of short-course HDMP on induction of a myeloprotective effect when administered before consolidation therapy consisting of high-dose cytosine arabinoside and daunorubicin. Thirty-four consecutive newly diagnosed children with acute myeloblastic leukemia (AML) who received 64 courses of consolidation regimen were entered into the study. The patients received HDMP (group A) at a daily dose of 30 mg/kg methylprednisolone starting 4 days before the initiation of consolidation therapy. The control group did not receive HDMP (group B). There were no differences in the white blood cell (WBC) and absolute neutrophil counts (ANC) between group A (at day -4) and group B (at day 0) at the beginning of the study (medians: 3 · 10 9 /L vs. 3.2 · 10 9 /L and 1.5 · 10 9 /L vs. 1.7 · 10 9 /L, respectively). The WBC count increased significantly from 3 · 10 9 /L to 6.4 · 10 9 /L, and ANC increased from 1.5 · 10 9 /L to 3.9 · 10 9 /L after 4 days of HDMP treatment in group A (P < 0.01). Following high-dose chemotherapy, the median values of WBC and ANC also remained higher than the control values during the 16 days of the follow-up period. The neutropenic period was significantly shorter in the HDMP group than in the control group (9 ± 5.2 days vs. 22 ± 4.7 days) (P < 0.05). The duration of hospitalization and the interval between two chemotherapy cycles were significantly decreased in group A when compared group B (9 ± 2.7 vs. 14 ± 2.7 days; 22 ± 4.7 vs. 26 ± 4.2 days, respectively) (P < 0.05). Moreover, following consolidation therapy, the number of patients with ANC values below 0.5 · 10 9 /L was lower in group A when compared the group B. In conclusion, the administration of short-course (4 days) HDMP before high-dose chemotherapy has been found to be beneficial for reducing the duration and severity of neutropenia. Further studies with short-course HDMP are required to evaluate its myeloprotective effects in patients with other malignancies.

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Current Awareness

2001

Hematological Oncology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of hematological oncology. Each bibliography is divided into 14 sections: 1 Books, Reviews & Symposia; 2 General; Leukemias: 3 Lymphoblastic; 4 Myeloid & Myelodysplastic Syndromes; 5 Chronic; 6 Others; Lymphomas: 7 Hodgkin's; 8 Non‐Hodgkin's; 9 Plasmacytomas/Multiple Myelomas; 10 Others; 11 Bone Marrow Transplantation; 12 Cytokines; 13 Diagnosis; 14 Cytogenetics. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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A Novel Approach to Treatment With High-Dose Steroid as a Differentiation Inducer in Children With Acute Myeloblastic Leukemia

Cited by 3 publications

References 13 publications

Varicella infection with childhood hematological malignancy: A single institution experience of 27 cases

Varicella infection with childhood hematological malignancy: A single institution experience of 27 cases

Myeloprotective effect of short‐course high‐dose methylprednisolone treatment before consolidation therapy in children with acute myeloblastic leukemia

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