A Novel Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Biomarker—Anti-DSG2—Is Absent in Athletes With Right Ventricular Enlargement

Abstract

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Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease

“…This is in contrast with both studies by Chatterjee et al and Caforio et al, which found significantly more frequent and greater concentrations of autoantibodies in people affected with ARVC compared to healthy controls. A more recent study assessing healthy human athletes with physiologic right ventricular enlargement found that anti-desmoglein-2 antibodies were not present, indicating further that they may play pathologic role 22 . However, Caforio et al also assessed heathy relatives of people with ARVC and patients with noninflammatory and ischemic cardiac disease as well as healthy unrelated blood donors, finding that anti-heart and anti-intercalated disc antibodies were present in some of these patients, albeit at a lower frequency compared to patients with ARVC and affected relatives.…”