Increasingly, cyber security personnel are using cyber deception defense techniques to deal with network intrusions. However, traditional cyber deception techniques (such as honeypots and honeynets) are easily detected by attackers, thus leading to failure. Therefore, we propose a cyber deception defense method based on the signal game to improve the effectiveness of the defense. More specifically, first, we propose a moving target defense (MTD) enhanced cyber deception defense mechanism. Then, on the basis of the in-depth analysis of network attack and defense scenarios, a signal game model is constructed to describe the network attack and defense process, and a multistage attack and defense game equilibrium solution method is designed to guide the selection of the optimal deception defense strategy. Meanwhile, considering the actual network attack and defense, we quantify the game revenue based on a probabilistic model. The experimental results show that the defense method proposed in this paper could guide the defender to implement the optimal defense strategy and achieve a better defense effect.