2018
DOI: 10.5415/apallergy.2018.8.e31
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A novel Australian tick Ixodes (Endopalpiger) australiensis inducing mammalian meat allergy after tick bite

Abstract: Tick-induced mammalian meat allergy has become an emergent allergy world-wide after van Nunen et al. first described the association between tick bites and the development of mammalian meat allergy in 2007. Cases of mammalian meat allergy have now been reported on all 6 continents where humans are bitten by ticks, in 17 countries - Australia, United States of America (USA), Europe (France, Spain, Germany, Belgium, Switzerland, Sweden, United Kingdom, Italy, and Norway), Asia (Korea and Japan), Central America … Show more

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Cited by 37 publications
(21 citation statements)
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“…Based on these studies, along with case reports of IgE-mediated anaphylactic reactions to meat cropping up in areas outside the south, it is projected that mammalian meat allergy associated with lone star ticks will increase in future years. Multiple case reports have been further published describing the association between α-gal IgE and meat allergy in Central America ( 1 , 3 , 4 ), Europe ( 5 7 ), Australia ( 2 , 20 ), Asia ( 8 , 9 ), and South Africa ( 21 ). Ticks are endemic in all of these regions yet vary in species.…”
Section: Introductionmentioning
confidence: 99%
“…Based on these studies, along with case reports of IgE-mediated anaphylactic reactions to meat cropping up in areas outside the south, it is projected that mammalian meat allergy associated with lone star ticks will increase in future years. Multiple case reports have been further published describing the association between α-gal IgE and meat allergy in Central America ( 1 , 3 , 4 ), Europe ( 5 7 ), Australia ( 2 , 20 ), Asia ( 8 , 9 ), and South Africa ( 21 ). Ticks are endemic in all of these regions yet vary in species.…”
Section: Introductionmentioning
confidence: 99%
“…Alpha-gal syndrome is mediated by an IgE antibody response against an epitope present in the mammalian oligosaccharide, galactose-alpha-1,3-galactose (alpha-gal). This allergic reaction is attributed to the bite of certain tick species and is considered to be an emerging condition around the world [122,123]. Several hundred to several thousand cases have been documented in North America, Europe, Australia and Japan; single cases have been reported from South America and Africa [124].…”
Section: Tick Bite-associated Complicationsmentioning
confidence: 99%
“…The AGS is becoming a global problem with increasing prevalence in all continents, and several tick species have been implicated in these disorders [10, 15] (Additional file 1: Figure S1). Remarkably, most of the patients that become allergic, had tolerated red meat for many years before being sensitized by tick bites [10].…”
Section: What Is the Alpha-gal Syndrome (Ags)?mentioning
confidence: 99%
“…Remarkably, most of the patients that become allergic, had tolerated red meat for many years before being sensitized by tick bites [10]. This finding suggests that while IgG and IgM antibody responses to α-Gal produced by some bacteria of the gut microbiota are beneficial as they protect against infection by pathogens such as malaria parasites and tuberculosis mycobacteria, anti-α-Gal IgE antibodies induced by tick bites break the oral tolerance to food allergens and induce anaphylactic reactions to tick α-Gal-containing salivary proteins [715].…”
Section: What Is the Alpha-gal Syndrome (Ags)?mentioning
confidence: 99%