A Novel Biocompatible Herbal Extract‐Loaded Hydrogel for Acne Treatment and Repair

Abstract

A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract-loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti-inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate-high antioxidative and anti-inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty-four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract-loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.

Therapeutic potential of nanoceria pretreatment in preventing the development of urological chronic pelvic pain syndrome: Immunomodulation via reactive oxygen species scavenging and SerpinB2 downregulation

“… 23 Oxidative stress is often accompanied by pro‐inflammatory cytokine expression. 24 , 25 qPCR assays of interleukin 6 ( Il6 ) and tumor necrosis factor α ( Tnfα ) were performed in each group of cells. The four groups of cells were collected and subjected to RNA extraction for qPCR assays.…”

Formulation and Evaluation of Herbal Sunscreens: An Assessment Towards Skin Protection from Ultraviolet Radiation

“…For two reasons, an acidic pH is essential for barrier homeostasis: first, two ceramide-synthesizing enzymes have low pH optima; and second, a low pH promotes the 13-nm long periodicity phase required for barrier construction. An acidic pH, in other words, generates a more effective barrier [26,29,31]. A lower skin surface pH is associated with greater resistance to SLS-induced irritating dermatitis, whereas patients with skin pH 5 have less scaling and higher moisture levels than those with skin pH > 5 [28,30].…”

“…After seven days of using herbal sunscreens, a skin irritation study found no irritation, sensitivity, or minor or patchy erythema (Table 2) [31].…”

Protective effect and mechanism research of Phyllanthus emblica Linn. fruit extract on UV-induced photodamage in keratinocytes

“…Research on PE extract has demonstrated its potential utility in natural healthcare products, such as food, health, and cosmetic products [47,48]. There is some evidence that suggests PE extract can have a positive impact on the skin, such as anti-aging, skin whitening and antioxidant properties [47,49,50]. However, more research is needed to fully understand the effects of PE extract on the skin and its optimal use as a topical treatment.…”