A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release

Bardajee, Ghasem Rezanejade; Hooshyar, Zari

doi:10.1007/s10965-013-0298-y

Cited by 51 publications

(19 citation statements)

References 58 publications

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“…1) observed between 3000 and 3628 cm-1 is linked to the O-H stretching of the glyosidic group present in the molecules of starch. These characteristics peaks are in accordance with literature [28,29]. The spectrum of pure PAA (Fig.…”

Section: Resultssupporting

confidence: 91%

“…[29] evaluated the S W of PAA-S blends in water and found out that the higher the amount of PAA in the sample, the greater the S W . A similar result was observed by Badajee et al [28], since the S W of PAA-S based films, developed in their work, increased with the increasing amount of acrylic acid present in the film. If the swelling in water is favored by increasing the proportion of PAA it is common to expect a different behavior in oil, as observed in the present work.…”

Section: Resultssupporting

confidence: 88%

“…Fonte não linear 77 G Gestões estratégicas 152 Inspetores Eletrônicos 162,163,168,169,171,172,173 K KAOS 60,61,62,63,64,65,66,67 M Modeling 30,32,34,35,36,37,44,60,61,64,66,67,111,135,136,139 N NASTRAN 13,15,16,19,20,21,22,25,26,27,28,29 O Olaria 174,175,182,183,184,185,186,187 Ontologia 30, 31 Otimização 13,15,16,18,20,21,22,…”

Section: íNdice Remissivounclassified

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Controle De Qualidade Dos Blocos Cerâmicos De Vedação De Seis E Oito Furos Das Olarias Do Amapá

Barbosa¹,

Pereira²,

Souza³

et al. 2020

Ampliação E Aprofundamento De Conhecimentos Nas Áreas Das Engenharias

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 88%

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Controle De Qualidade Dos Blocos Cerâmicos De Vedação De Seis E Oito Furos Das Olarias Do Amapá

Barbosa¹,

Pereira²,

Souza³

et al. 2020

Ampliação E Aprofundamento De Conhecimentos Nas Áreas Das Engenharias

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“…As a result, a slight decrease in the swelling ratio was observed. 65 The results clearly demonstrated that the prepared hydrogels possessed pH-sensitive characteristics, which facilitated their application in the controlled delivery of drugs.…”

Section: Swelling Behaviour Studymentioning

confidence: 84%

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

Wei

et al. 2015

J. Mater. Chem. B

127

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Salecan is a novel water-soluble extracellular b-glucan produced by a salt-tolerant strain Agrobacterium sp.ZX09. Salecan is suitable for the fabrication of hydrogels for biomedical applications due to its excellent physicochemical and biological properties. In this paper, a series of pH-sensitive hydrogels were prepared in aqueous solution by the graft copolymerization of Salecan and acrylic acid (AA) using N,N 0 -methylene diacrylamide as a crosslinker for controlled drug delivery. The structure and thermal stability of the resulting hydrogels were characterized by FT-IR, XRD and TGA. By SEM analysis, freeze-dried hydrogels displayed an interconnected porous structure with tunable pore size in the range of 23.2-90.3 mm. The swelling behavior of the hydrogels was shown to be highly dependent on the environmental pH, salt type and concentration, as well as the contents of Salecan and BAAm. They are almost unswellable at pH 1.2 and swollen extensively at pH 6.86. Meanwhile, the increase in the content of hydrophilic Salecan could enhance the swelling ratio, whereas the presence of more BAAm reduced the swelling capacity but promoted the water retention to some extent. Rheological tests revealed that storage modulus G 0 was strongly influenced by the crosslink density of the obtained hydrogel network.Especially, doxorubicin (DOX) as a model anti-cancer drug was very efficiently loaded into the negatively charged hydrogels (up to 69.4 wt%) through electrostatic interactions. More importantly, the release of DOX from this intelligent system exhibited pH-responsive behavior and a sustained release pattern. For SPA2, the cumulative release profile showed a low level of drug release (about 12.3 wt% in 24 h) at pH 7.4, and was significantly accelerated at pH 4.0 (over 40 wt% in 6 h). Cytotoxicity experiments confirmed that all blank hydrogels were non-toxic to A549 cells, while DOX released from the drug-loaded hydrogels remained biologically active and had the capability to kill cancer cells. The preliminary results clearly suggested that the Salecan-g-PAA hydrogels may be promising carriers for controlled drug delivery.

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“…Democracia energética 47, 51, 52 Desenvolvimento 15,47,52,53,54,55,56,58,60,61,63,64,67,75,98,102,111,112,114,120,122,152,164,178,190,191,192,193,194,196,197 153,156,162 Filmes 113,114,115,116,117,118,119,120,121,122 Flambagem 13,15,18,20,21,24,27,28 Fonte de corrente Howland 77, 89…”

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confidence: 99%

Avaliação Da Prontidão Da Organização De Ait De Satélites Artificiais Para O Atendimento De Requisitos De Seus Stakeholders

Silva¹,

Genaro²,

Silva³

et al. 2020

Ampliação E Aprofundamento De Conhecimentos Nas Áreas Das Engenharias

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release

Cited by 51 publications

References 58 publications

Controle De Qualidade Dos Blocos Cerâmicos De Vedação De Seis E Oito Furos Das Olarias Do Amapá

Controle De Qualidade Dos Blocos Cerâmicos De Vedação De Seis E Oito Furos Das Olarias Do Amapá

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

Avaliação Da Prontidão Da Organização De Ait De Satélites Artificiais Para O Atendimento De Requisitos De Seus Stakeholders

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