A novel biogenic Allium cepa leaf mediated silver nanoparticles for antimicrobial, antioxidant, and anticancer effects on MCF-7 cell line

Mani, M.; Okla, Mohammad K.; Selvaraj, S.; Kumar, A. Ram; Kumaresan, S.; Muthukumaran, Azhaguchamy; Kaviyarasu, K.; El-Tayeb, Mohamed A.; Elbadawi, Yahya B.; Almaary, Khalid S.; Almunqedhi, Bander; Elshikh, Mohamed S.

doi:10.1016/j.envres.2021.111199

Cited by 73 publications

(18 citation statements)

References 42 publications

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“…Similarly, previous findings supported this study regarding the inhibition concentration of AgNPs being 18 μg/mL [ 40 ]. In agreement with previous reports, at lower concentrations, toxicity is negligible [ 47 , 63 , 64 ]. However, the foregoing results suggest that the synthesized AgNPs could be potentially useful in synthesizing diabetes-related drugs, as well as could be a potential substitute for human breast cancer therapy.…”

Section: Discussionsupporting

confidence: 93%

Biogenic Synthesis, Characterization, and In Vitro Biological Evaluation of Silver Nanoparticles Using Cleome brachycarpa

Sumra

Zain

Saleem

et al. 2023

Plants

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The therapeutical attributes of silver nanoparticles (Ag-NPs) in both conditions (in vitro and in vivo) have been investigated using different plants. This study focused on the green chemistry approach that was employed to optimize the synthesis of silver nanoparticles (AgNPs) using Cleome brachycarpa aqueous extract as a reducing and stabilizing agent. The characterization of obtained CB-AgNPs was undertaken using UV-visible spectroscopy, Atomic-force microscopy (AFM), Fourier-Transform Infrared Spectroscopy (FTIR), scanning electron microscopy (SEM), and Energy-Dispersive X-ray (EDX) analysis. Results suggest that CB-AgNPs synthesized via stirring produced small-sized particles with more even distribution. The synthesized silver nanoparticles were spherical with a 20 to 80 nm size range. In vitro studies were used to analyze antioxidant, antidiabetic, and cytotoxic potential under different conditions. The results also indicated that CB-AgNPs may have significant potential as an antidiabetic in low concentrations, but also exhibited potential antioxidant activity at different concentrations. Moreover, the anticancer activity against the breast cell line (MCF-7) with IC50 reached up to 18 μg/mL. These results suggest that green synthesized silver nanoparticles provide a promising phytomedicine for the management of diabetes and cancer therapeutics.

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Section: Discussionsupporting

confidence: 93%

Biogenic Synthesis, Characterization, and In Vitro Biological Evaluation of Silver Nanoparticles Using Cleome brachycarpa

Sumra

Zain

Saleem

et al. 2023

Plants

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show abstract

“…There is an urgent need to develop new effective alternatives to solve the problem of resistance, associating nanotechnology with health science, to combine the synergistic effects of nanomaterials with their specific properties [4][5][6][7][8]. Recently, the application of nanomaterials with antibacterial activity, such as silver (AgNPs) [9,10] and zinc nanoparticles [11], has been attracted due to the flexibility on the application of these nanoparticles (such as on surfaces infected for bacteria) and due to the possibility to obtain low-cost materials using green synthesis (biosynthesis).…”

Section: Introductionmentioning

confidence: 99%

Green Nanoarchitectonics of Silver Nanoparticles for Antimicrobial Activity Against Resistant Pathogens

Chuy

Muraro

Viana

et al. 2021

J Inorg Organomet Polym

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“…Some alliums also show anti-proliferative effects on MCF-7 cells [13], [25]. However, they have shown great antiproliferative effects on MCF-7 cells, and the extracts used for those experiments are derived from the roots and owers (containing organosulfur compounds or saponins) of allium species.…”

Section: Inhibition Of Mcf-7 Cancer Cell Growthmentioning

confidence: 99%

Effect of subfractions of Allium mongolicum Regel methanolic extract on the proliferation of HepG2 and MCF-7 cells

Sandagsuren,

Enkhtsetseg,

Tsolmon

2024

Preprint

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The aerial part of Allium mongolicum Regel (AMR) which is abundant in the southeastern regions of Mongolia, is used as a food spice. When the crude extracts of this plant were prepared and used for the experiments different biological activities were observed because the extracts contained many polar to nonpolar compounds. This study aimed to prepare subfractions from the crude methanolic extract of AMR and to compare their antiproliferative effects on human cancer cells (HepG2, and MCF-7 cells). The methanolic extracts of AMR were fractionated into six subfractions (methanol, hexane, dichloromethane, ethyl acetate, butanol, and water residue) by solvent-solvent partitioning. The total phenolic content (TPC) was measured by the Folin-Ciocalteu assay. The antioxidant activity of the sub-fractions was determined via DPPH• and ABTS•+ assays. Subfraction antiproliferative activity on human cancer cells, HepG2 and MCF-7 cells, was determined by MTT assay. Subfractions showed completely distinct antioxidant and antiproliferative activities (p < 0.001). The highest TPC was in the ethyl acetate fraction (165.4 ± 0.5 mg GAE/g), and the TPC following the addition of dichloromethane, butanol, and methanol. The lowest two were in the n-hexane and water residue fractions. The ethyl acetate fraction showed the highest free radical scavenging activity in both the DPPH• and ABTS•+ assays (660.0 ± 5.24 µM TE/g dw the DPPH• assay; 312.7 ± 5.6 µM TE/g dw the ABTS•+ assay). The dichloromethane subfraction affected HepG2 cell proliferation and reduced viable cancer cells. Additionally, the dichloromethane and hexane subfractions affects MCF-7 cell proliferation by reducing the number of viable cancer cells. Subfraction methanolic extract by solvent partitioning is helpful for identifying biologically active compounds that show antiproliferative activity.

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A novel biogenic Allium cepa leaf mediated silver nanoparticles for antimicrobial, antioxidant, and anticancer effects on MCF-7 cell line

Cited by 73 publications

References 42 publications

Biogenic Synthesis, Characterization, and In Vitro Biological Evaluation of Silver Nanoparticles Using Cleome brachycarpa

Biogenic Synthesis, Characterization, and In Vitro Biological Evaluation of Silver Nanoparticles Using Cleome brachycarpa

Green Nanoarchitectonics of Silver Nanoparticles for Antimicrobial Activity Against Resistant Pathogens

Effect of subfractions of Allium mongolicum Regel methanolic extract on the proliferation of HepG2 and MCF-7 cells

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