A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides

Abstract

The power of pyrrole: a 1,6-self-immolative spacer designed on the pyrrole structure enables direct late-stage functionalisation of drugs and their traceless release under enzymatic or reductive micellar catalysis in water.