This paper studies the guidance scheme for the terminal guidance problem subject to input constraints, attack angle constraints, and second-order dynamics of missile autopilot. Firstly, the guidance system model with the above multi-constraint model is given. Secondly, an anti-saturation back-stepping guidance law which makes use of the low-pass filter to avoid the differential of the virtual control signals is designed based on the terminal sliding mode method, auxiliary system, and adaptive technique. Finally, Lyapunov theory and numerical simulations are utilized to prove that the states of the system under the proposed guidance law are uniformly ultimately bounded.