A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons

Abstract

In this study, we determined mode of action of a novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) on hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents (Ih) that plays important roles in neuropathic pain. In small or medium-sized dorsal root ganglion (DRG) neurons (<40 µm in diameter) exhibiting tonic firing and prominent Ih, SKL-NP inhibited Ih and spike firings in a concentration dependent manner (IC50=7.85 µM). SKL-NP-induced inhibition of Ih was blocked by pretreatment of pertussis toxin (PTX) and N-ethylmaleimide (NEM) as well as 8-Br-cAMP, a membrane permeable cAMP analogue. These results suggest that SKL-NP modulates Ih in indirect manner by the activation of a Gi-protein coupled receptor that decreases intracellular cAMP concentration. Taken together, SKL-NP has the inhibitory effect on HCN channel currents (Ih) in DRG neurons of rats.

Retraction: A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons

“…We would like to request a retraction of our paper [ 1 ] entitled, "A novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents in rat dorsal root ganglion neurons" by Gehoon Chung, Tae-hyung Kim, Hyewon Shin, Eunhee Chae, Hanju Yi, Hongsik Moon, Hyun Jin Kim, Joong Soo Kim, Seog Bae Oh, from The Korean Journal of Physiology & Pharmacology. Vol 16 (4) 237-241, 2012.…”