A novel catalyst‐free mechanochemical protocol for the synthesis of 2,3‐dihydro‐1<i>H</i>‐perimidines

Harry, Nissy Ann; Radhika, Sankaran; Neetha, Mohan; Anilkumar, Gopinathan

doi:10.1002/jhet.3880

Cited by 21 publications

(9 citation statements)

References 31 publications

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“…Harry et al [115] recently developed a new and facile eco-friendly mechanochemical synthesis of perimidines from NDA and carbonyl compounds in excellent yields applying catalyst and solvent-free conditions via grinding techniques. This protocol has several advantages like synthesis of library of perimidines (25 derivatives), ambient conditions, mild protocol, simple work-up, gram-scale synthesis, high atom economy, etc.…”

Section: Scheme 12 Catalyst-free Perimidine Synthesis In Different Comentioning

confidence: 99%

Recent Advances in the Synthesis of Perimidines and their Applications

Sahiba¹,

Agarwal²

2020

Top Curr Chem (Z)

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Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.

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Section: Scheme 12 Catalyst-free Perimidine Synthesis In Different Comentioning

confidence: 99%

Recent Advances in the Synthesis of Perimidines and their Applications

Sahiba¹,

Agarwal²

2020

Top Curr Chem (Z)

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“…Hence, the scientific society has shown great interest in the synthesis of heterocyclic compounds, especially via more eco‐friendly pathways. Our group has also contributed in this area [8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound irradiation in heterocycle synthesis: An overview

Saranya

Radhika

Abdulla

et al. 2021

Journal of Heterocyclic Chem

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The synthesis of heterocyclic compounds has been a hot topic for several decades. Synthetic organic chemists are always in search of new methodologies which are greener for the synthesis of heterocyclic compounds. The ultrasound‐assisted reactions have contributed much to this field. This review focuses on the impact of sonochemistry in the synthesis of heterocyclic compounds and covers the literature from 2009 to 2020.

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“…This allows their use in various scientific fields. They are characterized by either a bond deficit or an excess Π bond due to the electron density movements of the nitrogen atoms present in the naphthalene ring [4]. These compounds have a very important interest because of their polyvalent [5], optoelectronic, chemotherapeutic, thermochromic, and photochromic properties.…”

Section: Introductionmentioning

confidence: 99%

“…These compounds have a very important interest because of their polyvalent [5], optoelectronic, chemotherapeutic, thermochromic, and photochromic properties. They are still used with applications [6] in plasma display panels, organic solar cells and optical recording media [4]. 1-H perimidines are used in medical chemistry as antifungal, antimicrobial, antiulcer [7] and antitumor agents.…”

Section: Introductionmentioning

confidence: 99%

Quantative STRUCTURE Activity Relationship (QSAR) Study of a Series of Molecules Derived from 2,3-dihydro-1H- perimidine having Activity against Protein Tyrosine Phosphatase 1B

Tiéba

Stephane

Soro

et al. 2021

IRJPAC

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In order to study the Quantitative Structure Activity Relationship (QSAR) against protein tyrosine phosphatase 1B and descriptors, we used a series of fourteen (14) molecules derived from perimidine. The compounds were optimized at the computational level B3LYP / 6-31 G (d, p), to obtain the descriptors of the model. This study was performed using the Linear Multiple Regression (MLR) method. This tool allowed us to obtain a quantitative model from the descriptors that are, the overall softness (S), the energy of the lowest vacant (ELUMO), the bond length l (N-C1). This model has good statistical performance (R2 = 0.958; RMCE = 0.110; F = 43.870). In addition, the external validation test of Tropsha and the domain of applicability from the levers were verified.

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A novel catalyst‐free mechanochemical protocol for the synthesis of 2,3‐dihydro‐1H‐perimidines

Cited by 21 publications

References 31 publications

Recent Advances in the Synthesis of Perimidines and their Applications

Recent Advances in the Synthesis of Perimidines and their Applications

Ultrasound irradiation in heterocycle synthesis: An overview

Quantative STRUCTURE Activity Relationship (QSAR) Study of a Series of Molecules Derived from 2,3-dihydro-1H- perimidine having Activity against Protein Tyrosine Phosphatase 1B

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