A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

Menon, Deepthy; Thomas, Reny Thankam; Narayanan, Sreeja; Maya, S.; Jayakumar, R.; Hussain, Firasat; Lakshmanan, Vinoth-Kumar; Nair, Shanti V.

doi:10.1016/j.carbpol.2010.12.030

Cited by 75 publications

(43 citation statements)

References 23 publications

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“…Chitosan combination was also used by Menon et al (90) for therapeutic drug delivery. Nano-complexes of chitosan and polyoxometalates (POM) were tested as anti-cancer preparation.…”

Section: Chitosanmentioning

confidence: 99%

Nanotechnology in Drug Delivery

Villiers¹,

Aramwit²,

Kwon³

2009

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“…Chitosan combination was also used by Menon et al (90) for therapeutic drug delivery. Nano-complexes of chitosan and polyoxometalates (POM) were tested as anti-cancer preparation.…”

Section: Chitosanmentioning

confidence: 99%

Nanotechnology in Drug Delivery

Villiers¹,

Aramwit²,

Kwon³

2009

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“…Among the examples, CS and its derivatives were used to encapsulate Eu [39,40], Ti [41] or Co [42] substituted polyoxotungstates, so to enhance their cell-penetration, in order to develop nanomedicinal agents. In other cases, charged multilayered films of CS, and POMs were used as oxidation catalysts [43,44], H 2 O 2 sensors [45], electrocatalysts [46,47] and for the preparation of luminescent films [47].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Polyoxometalate Nanocomposites: Synthesis, Characterization and Application as Antimicrobial Agents

et al. 2014

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Polyoxometalates (POMs) were used, together with chitosan (CS), to obtain hybrid nanoaggregates. Three representative POMs were efficiently assembled into nanoparticles of few hundred nm diameter, featuring entangled ribbons substructure. In order to establish suitable preparation and stability conditions, the assemblies were characterized in solution by UV-Vis spectroscopy, dynamic light scattering and f-potential. The nanoparticles were tested against E. coli (10 6 CFU/ ml) in aqueous solution, showing a synergic activity of the heteropolyacid H 5 PMo 10 V 2 O 40 and CS. For such components, a highly porous and antibacterial film was obtained upon lyophilisation of the colloidal mixture.

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“…FT-IR spectrum of CSYC100 is represented in Fig. 1a, which signifies all the characteristic peaks of chitosan at 3420/cm appeared, and this can be credited to the -NH 2 and -OH groups stretching vibration and a peak at 1620/cm for the amide similar to as characterized earlier [12][13][14]. FT-IR spectrum of bare CoW 11 CpTi denoted in Fig.…”

Section: Resultsmentioning

confidence: 51%

“…1b) shows all the representative peaks existing in bare CoW 11 CpTi representing successful complex development. Furthermore, the peak at 1060/cm corresponds to the bridge oxygen (C-O-C) stretching bands [12][13][14]. DLS analysis portrayed hydrodynamic size of the nanocomposites (Fig.…”

Section: Resultsmentioning

confidence: 99%

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

Pandya

Joshi

2017

Asian J Pharm Clin Res

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Objectives: Polyoxometalates (POMs) are proved to be important for applications in medicine and in material science. Here, we represent nanocomposite formation of tungsten-containing potent anticancer polyanion, K 6 H [CoW 11 O 39 (CpTi)].13H 2 O (CoW 11 CpTi) with biocompatible ChitosanYC-100 (CSYC100) with the goal to reduce its heavy metal toxicity. Methods:Synthesis of "POM-CSYC100 nanocomposite" was attained without the aid of any cross-linker through electrostatic interaction technique. Nanocomposites were characterized using Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and thermogravimetric analysis. The release profile recorded was slow and sustained at physiological pH. In vitro cytotoxicity assays which show an attribute to reduce the toxicity of these POM were performed on C2C12 (mouse myoblast cell line) and A-549 (lung cancer cell line), which proved the reduced toxicity of nanocomposites as compared to the bare drugs.Results: Sustained release studies showed there was a slow and steady release of CoW 11 CpTi for 11 hrs, with the 98% of collective release at the end. From in vitro cytotoxic assay, it was deduced that CoW 11 CpTi -CSYC100 nanocomposite at the concentrations of 1.25 mM, and lower did not exhibit toxic effect on C2C12 cells as 95% total C2C12 cell mass remained viable. While in the case of A549 cells highest 5 mM concentration of bare CoW 11 CpTi is toxic to the cancer cells and after encapsulation cell viability increases from 10% to 55%. Conclusion:Thus, this study has designated the probability of using POM-chitosan nanocomposite for less toxic and effective biomedicinal applications.

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A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

Cited by 75 publications

References 23 publications

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery

Chitosan-Polyoxometalate Nanocomposites: Synthesis, Characterization and Application as Antimicrobial Agents

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

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