A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model

Kumar, Sarvesh; Mabalirajan, Ulaganathan; Rehman, Rakhshinda; Singh, Brajendra K.; Parmar, Virinder S.; Prasad, Ashok K.; Biswal, Shyam; Ghosh, Balaram

doi:10.1016/j.intimp.2012.10.024

Cited by 10 publications

(11 citation statements)

References 30 publications

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“…ROS, via direct signaling or oxidative modification of lipids, proteins and DNA, are believed to play a vital role in maintaining chronic inflammatory processes [ 2 , 3 , 42 ]. 8-oxoG is one of the most-documented forms of DNA base damage in the genome of constituent lung cells [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] and lungs of animal disease models [ 51 ]. Available reports provide strong evidence for the accumulation of 8-oxoG in DNA (and RNA) by inflammatory cell(s)—associated ROS, and ROS induced by environmental lung exposures and 8-oxoG have been acknowledged as an oxidative bio-marker [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

Aguilera-Aguirre

Rashid

et al. 2014

IJMS

107

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Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine’s lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.

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Section: Resultsmentioning

confidence: 99%

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

Aguilera-Aguirre

Rashid

et al. 2014

IJMS

107

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“…For example, a cinnamate compound enhances normal mitochondrial function, and reduces ROS production and mitochondrial fission, suggesting this drug as a good candidate for asthma treatment [200]. Similarly, Rd, a major ginsenoside component found in Panax ginseng , has been shown to ameliorate mitochondrial dysfunction in brain cells of a rat model for stroke [201], raising the possibility that this compound may have comparably beneficial effects on airway diseases.…”

Section: Targeting Mitochondria In Therapymentioning

confidence: 99%

Mitochondria in lung diseases

Aravamudan

Thompson

Pabelick

et al. 2013

Expert Review of Respiratory Medicine

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Summary Mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering, and cell fate determination. Regulation of their morphology and diverse activities beyond energy production are being recognized as playing major roles in cellular health and dysfunction. This review is aimed at summarizing what is known regarding mitochondrial contributions to pathogenesis of lung diseases. Emphasis is given to understanding the importance of structural and functional aspects of mitochondria in both normal cellular function (based on knowledge from other cell types) and in development and modulation of lung diseases such as asthma, COPD, cystic fibrosis and cancer. Emerging techniques that allow examination of mitochondria, and potential strategies to target mitochondria in the treatment of lung diseases are also discussed.

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“…Further, we reported that ETMTC increases the levels of NQO1-ARE mediated luciferase reporter activity. NQO1-ARE luciferase activity was determined by using stably transfected Beas-2B cells after treatment with ETMTC or SFN as positive control or DMSO as solvent [17, 18]. These findings clearly demonstrate the possible molecular mechanism of ETMTC action for inhibiting cell adhesion molecules [31].…”

Section: Antioxidant Activity Of Etmtcmentioning

confidence: 99%

“…In search of novel small molecules from natural sources, we have been studying the genus Piper for many years and have reported their antioxidant and anti-inflammatory activities. We haveidentified many novel compounds from Piper species and synthesized their derivatives to study the structure activity relationships [18–20]. Herein, we have summarized the anti-inflammatory and antioxidant activities of Piper species and their constituents from our laboratories and independent groups across the world.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Properties of Piper Species: A Perspective from Screening to Molecular Mechanisms

Kumar¹,

Malhotra²,

Prasad³

et al. 2015

CTMC

Self Cite

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Identifying novel therapeutic agents from natural sources and their possible intervention studies has been one of the major areas in biomedical research in recent years. Piper species are highly important - commercially, economically and medicinally. Our groups have been working for more than two decades on the identification and characterization of novel therapeutic lead molecules from Piper species. We have extensively studied the biological activities of various extracts of Piper longum and Piper galeatum, and identified and characterized novel molecules from these species. Using synthetic chemistry, various functional groups of the lead molecules were modified and structure activity relationship (SAR) studies identified synthetic molecules with better efficacy and lower IC50 values. Moreover, the mechanisms of actions of some of these molecules were studied at the molecular level. The objective of this review is to summarize experimental data published from our laboratories and others on antioxidant and anti-inflammatory potentials of Piper species and their chemical constituents.

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A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model

Cited by 10 publications

References 30 publications

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

Mitochondria in lung diseases

Anti-Inflammatory and Antioxidant Properties of Piper Species: A Perspective from Screening to Molecular Mechanisms

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