A novel colorimetric and “turn-on” fluorescent sensor for selective detection of Cu2+

Li, Jiaxin; Zhou, Chen; Zhang, Huan; Hou, Yue; Pan, Qing-Qing; Sun, Jing; Li, Xiao

doi:10.1016/j.arabjc.2022.104176

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…The sensor was applied to detect changes in Cu(II) in HeLa cells incubated in growth medium supplemented with 50 μM CuCl 2 . From this starting point, many similar hydrazide Cu(II) probes that employ rhodamine ring-opening strategies have been developed and applied to detect exogenous addition of Cu(II) in various cell types such as rhodamine B variants with dimethylaminovinylbenzene ( 252 ), ethyl hydroxide (RO1; 253 ), 2-methylpiperidine ( 254 ), Furan-2-carbaldehyde ( 255 ), 3-chloropyridazine ( 256 ), or benzyl-methyl-triazole (RHT; 257 ) substitutions, or a bis-spirocyclic configuration ( 258 ); rhodamine 6G variants with methanethioamide ( 259 ), ethyl hydroxide ( 260 ), tert -butylpyrrolyl methanimine ( 261 ), or trifluoroacetaldehyde substitutions ( 262 ); and fluorescein variants with pyridinylmethanimine (FHP; 263 ) and nitrobenzo-oxadiazole substitutions (NF; 264 ) . Other hydrazide variants have employed rhodamines with extended π-conjugation for a red-shifted emission such those with a vinylbenzonitrile (CSCN-Cu; 265 ), a naphthylamine (BF-Cu; 266 ), a carbazole (MeCzR-Cu; 267 ), a biscarbazole (BCX-Cu; 268 ), a benzimidazole with a six-membered spirocyclic hydrazide (BiF-Cu; 269 ), a quinazolinone (RQNA; 270 ), a benzene (FLACu; 271 ), a diethyl-tetrahydroquinoxaline/julolidine (JRQN; 272 ), and a quinoline (QFH; 273 ) …”

Section: Fluorescent Sensors For Coppermentioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

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Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity-and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals: iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals. CONTENTS5908 8.2. Activity-Based Fluorescent Sensors for Ni(II) 5911 9. Outlook 5911 Author Information 5912 Corresponding Authors 5912

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Section: Fluorescent Sensors For Coppermentioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

show abstract

“…Nowadays there has been a growing interest in developing fluorescent compounds for sensory biological or environmental applications because they are easy to be synthesized, highly sensitive and inexpensive [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Moreover, the ongoing development of confocal microscopy and optical imaging technologies facilitate the utilization of theses fluorescent probes for biological imaging [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Associated 1,8-Naphthalimide as a Selective Fluorescent Chemosensor for Detection of High pH in Aqueous Solutions and Their Hg2+ Contamination

Said

Staneva

Angelova

et al. 2022

Sensors

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A novel diamino triazine based 1,8-naphthalimide (NI-DAT) has been designed and synthesized. Its photophysical properties have been investigated in different solvents and its sensory capability evaluated. The fluorescence emission of NI-DAT is significantly impacted by the solvent polarity due to its inherent intramolecular charge transfer character. Moreover, the fluorescence emission quenched at higher pH as a result of photo-induced electron transfer (PET) from triazine moiety to 1,8-naphthalimide after cleaving hydrogen bonds in the self-associated dimers. Furthermore, the new chemosensor exhibited a good selectivity and sensitivity towards Hg2+ among all the used various cations and anions in the aqueous solution of ethanol (5:1, v/v, pH = 7.2, Tampon buffer). NI-DAT emission at 540 nm was quenched remarkably only by Hg2+, even in the presence of other cations or anions as interfering analytes. Job’s plot revealed a 2:1 stoichiometric ratio for NI-DAT/Hg2+ complex, respectively.

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Design and Application of Cu2+ Fluorescent Sensor Based on Carbazole Derivatives

Li,

Xiao,

Zhou

et al. 2024

J Fluoresc

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A novel colorimetric and “turn-on” fluorescent sensor for selective detection of Cu2+

Cited by 10 publications

References 26 publications

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Self-Associated 1,8-Naphthalimide as a Selective Fluorescent Chemosensor for Detection of High pH in Aqueous Solutions and Their Hg2+ Contamination

Design and Application of Cu2+ Fluorescent Sensor Based on Carbazole Derivatives

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