A Novel Combined Method of Osteosynthesis in Treatment of Tibial Fractures: A Comparative Study on Sheep with Application of Rod‐Through‐Plate Fixator and Bone Plating

Tralman, G.; Andrianov, V. V.; Arend, Andres; Männik, Piret; Kibur, Ragnar Toomas; Nõupuu, Kalev; Uksov, Denis; Aunapuu, Marina

doi:10.1111/j.1439-0264.2012.01167.x

Cited by 8 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to small animal models, the predominant research topic is the examination of different fixation techniques. The study of nailing techniques or materials after artificial fracture 110,111 or osteotomy [112][113][114] even with an induced bacterial infection 115 as well as the study of different plating techniques or materials, [116][117][118] and the biomechanical influences of different fixation techniques in fracture healing are widely examined. [119][120][121][122][123][124][125][126][127][128][129] Technical influences on fracture healing, including ultrasound 130,131 or shockwave 132 are only rarely described in large animal models.…”

Section: Animal Modelsmentioning

confidence: 99%

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

Reifenrath

Angrisani

Lalk

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

In the field of fracture healing it is essential to know the impacts of new materials. Fracture healing of long bones is studied in various animal models and extrapolated for use in humans, although there are differences between the micro- and macrostructure of human versus animal bone. Unfortunately, recommended standardized models for fracture repair studies do not exist. Many different study designs with various animal models are used. Concerning the general principles of replacement, refinement and reduction in animal experiments (three "Rs"), a standardization would be desirable to facilitate better comparisons between different studies. In addition, standardized methods allow better prediction of bone healing properties and implant requirements with computational models. In this review, the principles of bone fracture healing and differences between osteotomy and artificial fracture models as well as influences of fixation devices are summarized. Fundamental considerations regarding animal model choice are discussed, as it is very important to know the limitations of the chosen model. In addition, a compendium of common animal models is assembled with special focus on rats, rabbits, and sheep as most common fracture models. Fracture healing simulation is a basic tool in reducing the number of experimental animals, so its progress is also presented here. In particular, simulation of different animal models is presented. In conclusion, a standardized fracture model is of utmost importance for the best adaption of simulation to experimental setups and comparison between different studies. One of the basic goals should be to reach a consensus for standardized fracture models.

show abstract

Section: Animal Modelsmentioning

confidence: 99%

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

Reifenrath

Angrisani

Lalk

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…We have reported the TTA CF technique on ovine model. Sheep are becoming popular as animal model in orthopedic research in both human and veterinary medicine [ 28 , 32 , 39 , 40 , 42 ]. In humans, the use dogs are reduced due to the emotional impact related to these kinds of animals [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…TTA CF titanium implants and special guides are dedicated for dogs affected by CCL insufficiency. The sheep was chosen as a model animal because the anatomy and biomechanics of the stifle joint are similar to dogs [ 28 , 32 , 39 , 40 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

A novel tibial tuberosity advancement technique with cranial implant fixation (TTA CF): a pilot study in sheep

Zhalniarovich

Mieszkowska

Przyborowska-Zhalniarovich

et al. 2018

BMC Vet Res

View full text Add to dashboard Cite

BackgroundCranial cruciate ligament rupture is the most frequent orthopedic disorder in human and animals. An array of surgical techniques have been described to stabilize the stifle joint in dogs, including intraarticular stabilization, extraarticular stabilization, and tibial osteotomy techniques. Tibial plateau leveling osteotomy and tibial tuberosity advancement with a lot of modifications are the most common. In this study we report the possibility of fixing the novel titanium implant for tibial tuberosity advancement with two screws in a craniocaudal direction. The aim of our study was to improve the clinical benefit of the tibial tuberosity advancement surgical technique where an attempt was made to reduce the number of screws and obtain a strong implant fixation with minimal bone traumatization. This way of attachment allows to distribute the forces evenly on medial and lateral side of osteotomy gap.ResultsTibial tuberosity advancement with cranial implant fixation was performed in four sheep. Complete radiographic and clinical follow up was recorded. All four sheep had a complete osteotomy line healing at a mean of 10 weeks postoperative (range 8–12 weeks). None of the animals had osteotomy gap healing grades of poor. Minor complication included the minimally cracked Maquet hole on the postoperative radiographs, without displacement of the tibial crest which occurred in 2 sheep. Major complication grade 1, major complication grade 2 and catastrophic were not found.ConclusionsThe novel surgical technique for tibial tuberosity advancement with cranial implant fixation is technically comparable to the recent trend in tuberosity advancement techniques, where partial osteotomy of the cranial tibial tuberosity crest is performed. A cranial implant fixation allows to distribute the forces evenly on medial and lateral side of osteotomy gap, which may result in less number of major complications in dogs. A novel titanium implant decreases the tibial traumatisation by reducing the number of screws.

show abstract

“…Complications from 6-8% have been noted [235,236]. Another attempt to have a more stable osteosynthesis is the rod-through-plate osteosynthesis with low complication rates [237]. The advantage of plate osteosynthesis for testing drug delivery systems is the accessibility of the defect.…”

Section: Sheepmentioning

confidence: 98%

Preclinical testing of drug delivery systems to bone

Griensven

2015

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

A Novel Combined Method of Osteosynthesis in Treatment of Tibial Fractures: A Comparative Study on Sheep with Application of Rod‐Through‐Plate Fixator and Bone Plating

Cited by 8 publications

References 22 publications

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

A novel tibial tuberosity advancement technique with cranial implant fixation (TTA CF): a pilot study in sheep

Preclinical testing of drug delivery systems to bone

Contact Info

Product

Resources

About