A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells

Cheng, Chen; Zheng, Nan; Sun, Deyang; Fang, Wei‐Shuo; Zheng, Ling‐Ling; Song, Weihong; Huang, Jian

doi:10.1007/s11064-020-03073-4

Neurochem Res

2020

DOI: 10.1007/s11064-020-03073-4

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A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells

Chen Cheng

Nan Zheng

Deyang Sun

et al.

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Cited by 2 publications

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Platinum‐Loaded Cerium Oxide Capable of Repairing Neuronal Homeostasis for Cerebral Ischemia‐Reperfusion Injury Therapy

Zhang,

Liu,

et al. 2024

Adv Healthcare Materials

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Effective neuroprotective agents are required to prevent neurological damage caused by reactive oxygen species (ROS) generated by cerebral ischemia‐reperfusion injury (CIRI) following an acute ischemic stroke. Herein, we aimed to develop the neuroprotective agents of cerium oxide loaded with platinum clusters engineered modifications (Ptn‐CeO2). The density functional theory (DFT) calculations showed that Ptn‐CeO2 could effectively scavenge ROS, including hydroxyl radicals (·OH) and superoxide anions (·O2−). In addition, Ptn‐CeO2 exhibited the superoxide dismutase‐ and catalase‐like enzyme activities, which is capable of scavenging hydrogen peroxide (H2O2). The in‐vitro studies showed that Ptn‐CeO2 could adjust the restoration of the mitochondrial metabolism to ROS homeostasis, rebalance cytokines, and featured high biocompatibility. The studies in mice cerebral ischemia‐reperfusion injury (CIRI) demonstrated that Ptn‐CeO2 could also restore cytokine levels, reduce cysteine aspartate‐specific protease (Cleaved Caspase 3) levels, and induce the polarization of microglia to M2‐type macrophages, thus inhibiting the inflammatory responses. As a result, Ptn‐CeO2 inhibited the reperfusion‐induced neuronal apoptosis, relieved the infarct volume, reduced the neurological severity score, and improved cognitive function. Overall, these findings suggest that the prominent neuroprotective effect of the engineered Ptn‐CeO2 has a significant neuroprotective effect and provides a potential therapeutic alternative for CIRI.This article is protected by copyright. All rights reserved

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Platinum‐Loaded Cerium Oxide Capable of Repairing Neuronal Homeostasis for Cerebral Ischemia‐Reperfusion Injury Therapy

Zhang,

Liu,

et al. 2024

Adv Healthcare Materials

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Neuroprotective Effects of Different Lavandula stoechas L. Extracts Against Hydrogen Peroxide Toxicity in vitro

Erdo¹,

Bayar²,

Ozkaya³

et al. 2022

International J. of Pharmacology

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A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells

Cited by 2 publications

References 58 publications

Platinum‐Loaded Cerium Oxide Capable of Repairing Neuronal Homeostasis for Cerebral Ischemia‐Reperfusion Injury Therapy

Platinum‐Loaded Cerium Oxide Capable of Repairing Neuronal Homeostasis for Cerebral Ischemia‐Reperfusion Injury Therapy

Neuroprotective Effects of Different Lavandula stoechas L. Extracts Against Hydrogen Peroxide Toxicity in vitro

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