Mechanisms causing greenhouse gas (GHG) emission in wastewater treatment plants are of great interest among researchers, encouraging the development of new methods for wastewater management. Wastewater treatment plants (WWTPs) emit three major greenhouse gases during the treatment processes: CO 2 , CH 4 , and N 2 O. Additional amounts of CO 2 and CH 4 are produced during energy consumption, which can be considered an indirect source of GHGs. Recently, several efforts have been undertaken to assess GHGs from WWTPs, with particular attention paid to the N 2 O assessment due to its high warming potential (300 times stronger than CO 2). This study proposes an integrated model platform for WWTP simulation, including the evaluation of both direct and indirect emissions as plant performance parameters. The results of extensive research demonstrate the importance of mathematical modeling for the development of a decision support system (DSS). The project involves four research units (RUs) united in effort to minimize the environmental impact of wastewater treatment plants in terms of both energy consumption and discharged pollutants (solids, liquids, and gases).