A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system

Wang, Yueyao; Wang, Ruiwen; Peng, Zhe; Li, Zunjiang; Qi, Zhongwen; Wu, Qiqi; Ding, Banghan

doi:10.1016/j.ecoenv.2024.116871

Ecotoxicology and Environmental Safety

2024

DOI: 10.1016/j.ecoenv.2024.116871

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A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system

Yueyao Wang,

Ruiwen Wang,

Zhe Peng

et al.

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2024

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Cited by 1 publication

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Computational insights into exploring the potential effects of environmental contaminants on human health

Cao,

Zhao,

et al. 2024

Preprint

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The rise in human activity has intensified environmental pollution, posing a global public health challenge. Understanding the intricate mechanisms by which pollutants impact health is crucial. Traditional research, often limited to specific techniques and short-term exposures, fails to capture the full complexity of these interactions. This study integrates machine-learning, quantum chemical computing, physicochemical properties, target prediction, KEGG and GO pathway analyses and survival analysis to examine the effects of air and water pollutants on human health. We chose knowledge-guided pre-trained graph transformer (KPGT) framework with an AUC of 0.83 knowledge bootstrap to predict the carcinogenic potential of pollutants and clustered environmental pollutants into seven different groups. For each group, quantum chemical and physicochemical properties, target prediction, KEGG and GO pathway analyses further revealed links between pollutants and cancer-related factors, such as MicroRNA, PD-L1, the PD-1 checkpoint pathway, and HIF-1 signaling. Survival analysis identified key proteins associated with poor cancer prognosis. These findings provide insights into the complex effects of pollutants on health and contribute to public health research.

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Computational insights into exploring the potential effects of environmental contaminants on human health

Cao,

Zhao,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system

Cited by 1 publication

References 41 publications

Computational insights into exploring the potential effects of environmental contaminants on human health

Computational insights into exploring the potential effects of environmental contaminants on human health

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