A novel copper (II) complex containing a tetradentate Schiff base: Synthesis, spectroscopy, crystal structure, DFT study, biological activity and preparation of its nano-sized metal oxide

Tohidiyan, Zeinab; Sheikhshoaie, Iran; Khaleghi, Moj; Mague, Joel T.

doi:10.1016/j.molstruc.2017.01.026

Cited by 28 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Energy gap of HOMO and LUMO shows the molecular chemical stability, which is a critical parameter in determining molecular electrical transport properties because it is a measure of electron conductivity. The optimized structure of the complexes suggests slightly distorted square planar geometry around the metal center and calculated bond length and bond angles are in accordance with the other reported square-planner copper(II) complexes of N,O donor ligands [26,27].…”

Section: Resultssupporting

confidence: 88%

Synthesis, Spectral Studies and DFT Calculation of Copper(II) Complexes with Mixed Ligands

Kumar¹,

Anjum²,

Jaiswal³

et al. 2018

Asian J. Chem.

View full text Add to dashboard Cite

Mixed ligand metal complexes of Schiff base derived from salicylaldehyde with aromatic amines have received significant attention in the recent years [1] because of their interesting physico-chemical properties [2], varied structural features [3] and biologically activities [4]. The high affinity for the chelation of the Schiff bases toward the copper metal ions is employed in synthesis of their important biologically potent coordination complexes. Therefore, significant work has been devoted to the synthesis and characterization of mixed ligand copper(II) complexes with several Schiff base ligands [5]. Electrochemical studies of some copper (II) complexes show that the complexes with lower reduction potential are more biologically active [6]. Copper complexes show significant antibacterial and antifungal activities [7]. Due to the presence of nitrogen and oxygen donor sites in the ligands in their backbones they form stable and intensely coloured coordination complexes of copper [8,9]. The occurrence of an amine group in the alkanolamine offers further possibilities of inter molecular hydrogen bond [10] formation with Schiff bases, which may lead to metal complexes with three-dimensional network structures. Survey of literature reveals that there is no report of synthesis and structural studies of complexes of copper with mixed ligand such as salicylidine-1-aminobenzene (sabH), salicylidene-4chloro-1-aminobenzene (scabH), salicylidene-4-methyl-1

show abstract

Section: Resultssupporting

confidence: 88%

Synthesis, Spectral Studies and DFT Calculation of Copper(II) Complexes with Mixed Ligands

Kumar¹,

Anjum²,

Jaiswal³

et al. 2018

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

“…[11] Copper is an essential trace metal element in the human body. Modern medical research shows that copper complexes can produce antibacterial, [12] antiviral, [13] anti-inflammatory, [14] antitumor, [15][16][17] enzyme inhibitory [18] or chemical nuclease activities, [19] which are increasingly attracting the attention of researchers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, antiproliferative activity, DNA binding and density functional theory calculations of 3‐(pyridin‐2‐yl)‐8‐tert‐butylcoumarin and its copper(II) complex

Shi

Nie

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

A Cu(II)–coumarin complex, [CuL2(NO3)2] (2), where L = 3‐(pyridin‐2‐yl)‐8‐tert‐butylcoumarin (1), was synthesized with Cu(NO3)2⋅3H2O and characterized using elemental, infrared and single‐crystal X‐ray diffraction analyses. The crystal structure of 1 shows that all the pyrone, benzene and pyridine rings are completely coplanar. The crystal structure of 2 is stabilized by intermolecular C–H···O and C–H···N hydrogen bonds and C···C short contacts, which lead to the formation of a two‐dimensional network structure. Density functional theory results give support to the experimentally determined monomeric structure. The in vitro cytotoxic activities of 1 and 2 were investigated against HeLa (cervical carcinoma), A549 (lung), HepG2 (liver) and HUVEC (umbilical vein) cells by MTT assay. The IC50 values show that both 1 and 2 have lower toxicity than doxorubicin and cisplatin in every case. Ligand 1 exhibits higher anti‐HeLa activity than doxorubicin. Complex 2 displays higher anti‐HeLa activity than coumarin but lower than that of cisplatin. Various spectroscopic approaches indicate that 1 and 2 could effectively bind with DNA through intercalation mode.

show abstract

“…Among these copper compounds occupy a place of choice. These complexes can be used in various fields such as molecular magnetism [9,10], catalysis [11,12], materials chemistry [13,14] and biology [15,16]. A potent inhibitor of DNA synthesis and cell growth has been reported in the literature ie.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic studies and X-ray structure determination of two mononuclear copper complexes derived from the Schiff base ligand N,N-dimethyl-N'-((5-methyl-1H-imidazol-4-yl)methylene)ethane-1,2-diamine

Haba

Tamboura

et al. 2019

Eur J Chem

View full text Add to dashboard Cite

Reactions of the Schiff base N,N-dimethyl-N'-((5-methyl-1H-imidazol-4-yl)methylene) ethane-1,2-diamine (HL), synthesised in situ, with chloride or thiocyanate copper (II) salt; afforded two new mononuclear complexes, [Cu(HL)Cl2]·H2O (1) and [Cu(HL)(SCN)2] (2). These compounds have been studied and characterized by elemental analysis, IR and UV-Vis spectroscopies, electrochemistry, molar conductivity and room temperature magnetic measurements. Single crystal X-ray structure determination of the complexes revealed the presence of neutral moieties in the asymmetric unit. The mononuclear (1) crystallises in the monoclinic space group P21/c with the following unit cell parameters a = 7.4355(3) Å, b = 7.2952(3) Å, c = 26.2729(11) Å, β = 93.461(4)°, V = 1422.52(10) Å3, Z = 4, R1 = 0.033 and wR2 = 0.082 and the mononuclear complex (2) crystallises in the monoclinic space group C2/c with the following unit cell parameters a = 26.2578(7) Å, b = 7.4334(2) Å, c = 16.6237(5) Å, β = 99.089(3)°, V = 3203.95(16) Å3, Z = 8, R1 = 0.037 and wR2 = 0.104. In both complexes the ligand acts in tridentate fashion and the coordination environment of the copper atom can be described as distorted square pyramidal. The crystal lattice of the complex 1 is stabilized by electrostatic forces of attraction and O–H···Cl, C–H···O, N–H···Cl, and C–H···Cl, hydrogen bonding interactions while the crystal lattice of the complex 2 is stabilized by N–H···S and C–H···N.

show abstract

A novel copper (II) complex containing a tetradentate Schiff base: Synthesis, spectroscopy, crystal structure, DFT study, biological activity and preparation of its nano-sized metal oxide

Cited by 28 publications

References 32 publications

Synthesis, Spectral Studies and DFT Calculation of Copper(II) Complexes with Mixed Ligands

Synthesis, Spectral Studies and DFT Calculation of Copper(II) Complexes with Mixed Ligands

Synthesis, crystal structure, antiproliferative activity, DNA binding and density functional theory calculations of 3‐(pyridin‐2‐yl)‐8‐tert‐butylcoumarin and its copper(II) complex

Synthesis, spectroscopic studies and X-ray structure determination of two mononuclear copper complexes derived from the Schiff base ligand N,N-dimethyl-N'-((5-methyl-1H-imidazol-4-yl)methylene)ethane-1,2-diamine

Contact Info

Product

Resources

About