2021
DOI: 10.1016/j.carpath.2021.107336
|View full text |Cite
|
Sign up to set email alerts
|

A novel coronavirus meets the cardiovascular system: Society for Cardiovascular Pathology Symposium 2021

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
8
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 13 publications
(9 citation statements)
references
References 46 publications
1
8
0
Order By: Relevance
“…Though far less frequent, examples of misidentified coronavirus can be found from the 2003 SARS‐CoV‐1 outbreak as well as from the 2012 MERS‐CoV outbreak (Alsaad et al, 2018 ; Ding et al, 2004 ). Misidentifications of SARS‐CoV‐2 particles have occurred in nearly every tissue of the body (Table 1 ), leading to possible confusion as to whether the virus itself is causing tissue damage throughout the body or if tissue damage is a result of other factors, like the cytokine storm or downstream complications due to lack of proper function of an infected organ (Buja & Stone, 2021 ; Gustine & Jones, 2021 ; Perico et al, 2021 ). To date, SARS‐CoV‐2 particles have been correctly identified by EM only in the lung, heart, olfactory mucosa, and placenta (Birkhead et al, 2021 ; Dittmayer et al, 2020 ; Martines et al, 2020 ; Meinhardt et al, 2020 ; Nardacci et al, 2021 ; Reagan‐Steiner et al, 2022 ).…”
Section: Coronavirus Misidentificationsmentioning
confidence: 99%
See 1 more Smart Citation
“…Though far less frequent, examples of misidentified coronavirus can be found from the 2003 SARS‐CoV‐1 outbreak as well as from the 2012 MERS‐CoV outbreak (Alsaad et al, 2018 ; Ding et al, 2004 ). Misidentifications of SARS‐CoV‐2 particles have occurred in nearly every tissue of the body (Table 1 ), leading to possible confusion as to whether the virus itself is causing tissue damage throughout the body or if tissue damage is a result of other factors, like the cytokine storm or downstream complications due to lack of proper function of an infected organ (Buja & Stone, 2021 ; Gustine & Jones, 2021 ; Perico et al, 2021 ). To date, SARS‐CoV‐2 particles have been correctly identified by EM only in the lung, heart, olfactory mucosa, and placenta (Birkhead et al, 2021 ; Dittmayer et al, 2020 ; Martines et al, 2020 ; Meinhardt et al, 2020 ; Nardacci et al, 2021 ; Reagan‐Steiner et al, 2022 ).…”
Section: Coronavirus Misidentificationsmentioning
confidence: 99%
“…Within cardiac tissue, disrupted endothelial cells resulting in direct contact of myocardial cells with the vascular lumen were noted in severe COVID‐19 cases (Duarte‐Neto et al, 2021 ). Recent reviews of clinical and autopsy studies from 2020 indicate that endothelial dysfunction during SARS‐CoV‐2 infection, such as those seen by EM, are key to inciting the inflammatory processes that cause more severe COVID‐19 (Buja & Stone, 2021 ; Perico et al, 2021 ).…”
Section: Ultrastructural Changes Caused By Sars‐cov ...mentioning
confidence: 99%
“…It must be emphasized that the viral infection can not only deregulate a pre-existing heart disease, but also exacerbate mild asymptomatic pre-existing heart failure with long-term complications. The increased risk of complications in patients with heart failure, various arrhythmias, post-infarction, and similar vulnerable conditions leads to a higher risk for suspected myocardial damage ( Figure 2 ) [ 81 , 82 , 83 ].…”
Section: Discussionmentioning
confidence: 99%
“…The co-existence of myocardial inflammation and interstitial edema with cardiac fibrosis, together with an abnormal regulation of the intracellular Ca ++ and K + concentrations can facilitate arrhythmias (especially tachyarrhythmias) and subsequently heart failure, further damaging the heart. In the worst scenario, the overall systemic damage may lead to a multi-organ failure (MOF) [ 1 , 9 , 78 , 80 , 81 , 82 , 83 ] Credits: Original figure by I.A. Charitos).…”
Section: Figurementioning
confidence: 99%
“…There are single case reports of virus-shaped particles [ 11 ] in cardiomyocytes; thus, direct infection might be possible in a subset of cases. However, the clinicopathological evidence remains scarce [ 24 ]. Another finding in COVID-19 autopsies was cardiac amyloidosis.…”
Section: Organ Specific Involvement In Covid-19mentioning
confidence: 99%