A novel COVID-19 and its effects on cardiovascular disease

Paramasivam, Arumugam; Priyadharsini, J. Vijayashree; Raghunandhakumar, Subramanian; Elumalai, Perumal

doi:10.1038/s41440-020-0461-x

Cited by 78 publications

(66 citation statements)

References 12 publications

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“…SARS-CoV-2 infection can indirectly induce myocardial injury due to a cytokine storm triggered by viral infection, which may lead to increased vascular wall permeability accompanied by myocardial oedema [ 7 ]. Furthermore, the virus causes inflammation and fluid retention in the alveoli, which then leads to hypoxia and subsequently impacts on cardiac output [ 8 ]. Ultimately, this may trigger myocardial injury, decompensated heart failure and increased risk of arrhythmias in patients with pre-existing CVD [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…COVID-19 may also directly induce pathological changes in the heart tissue due to viral replication within the myocardium [ 10 , 11 ]. Indeed, case studies on autopsy and endomyocardial biopsy reports showed evidence for an acute lymphocytic myocarditis, which may aggravate to inflammatory cardiomyopathy [ 8 , 12 , 13 ]. There is a unique interplay between COVID-19 and CVD.…”

Section: Introductionmentioning

confidence: 99%

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Interplay of COVID-19 and cardiovascular diseases in Africa: an observational snapshot

et al. 2020

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The COVID-19 pandemic, which started around December 2019 has, at present, resulted in over 450,000 deaths globally, and approximately 1% of these deaths have been reported in Africa. Despite the high prevalence of COVID-19 risk factors, namely: hypertension, diabetes, chronic pulmonary disease, cardiovascular diseases (CVDs) such as rheumatic heart disease, compromised immunity and obesity, low case fatality rates have been recorded in many parts of Africa so far. COVID-19 severity has previously been shown to be worse in patients with CVD and hypertension. We observed the severity of COVID-19 and mortality rates in Africa, and compared outcomes with prevalence of established risk factors (hypertension and CVD). We stratified data as per the United Nations’ 5 African subregions. North African countries show a positive association between the risk factors and the mortality rates from COVID-19. However, we observed discordant patterns in the relationship between COVID-19, and either CVD or hypertension, in sub-Saharan African countries. In this paper, we also review the pathogenesis of SARS-CoV-2 infection and how it worsens CVD and postulate that the differences in modulation of the renin–angiotensin–aldosterone system (RAAS) axis which controls angiotensin-converting enzyme (ACE)/ACE2 balance may be an important determinant of COVID-19 outcomes in Africa. Electronic supplementary material The online version of this article (10.1007/s00392-020-01720-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interplay of COVID-19 and cardiovascular diseases in Africa: an observational snapshot

et al. 2020

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“…Furthermore, the risk factor for mortality and morbidity due to the novel infectious coronavirus disease (COVID-19) is higher for people with chronic health conditions. The pandemic COVID-19 has also increased the demand for remote health-monitoring systems, especially for CVDs [ 2 , 3 ]. Sudden cardiac death and other heart problems can be avoided by using suitable prevention techniques, such as long-term monitoring of the heart signal and taking appropriate medication to prevent critical conditions [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device

Satti

Park

et al. 2020

Sensors

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Microneedle array electrodes (MNE) showed immense potential for the sensitive monitoring of the bioelectric signals by penetrating the stratum corneum with high electrical impedance. In this paper, we introduce a rigid parylene coated microneedle electrode array and portable electrocardiography (ECG) circuit for monitoring of ECG reducing the motion artifacts. The developed MNE showed stability and durability for dynamic and long-term ECG monitoring in comparison to the typical silver-silver chloride (Ag/AgCl) wet electrodes. The microneedles showed no mechanical failure under the compression force up-to 16 N, but successful penetration of skin tissue with a low insertion force of 5 N. The electrical characteristics of the fabricated MNE were characterized by impedance spectroscopy with equivalent circuit model. The designed wearable wireless ECG monitoring device with MNE proved feasibility of the ECG recording which reduces the noise of movement artifacts during dynamic behaviors.

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“…Several diagnostic studies are being conducted for early detection and prevention of cancers (Shree et al, 2019), similar studies can help in early detection and prevention of covid-19. A recent study has documented that COVID-19 can lead to heart injury, even in people without underlying heart issues (Paramasivam et al, 2020). Surprisingly there are studies that have shown that environmental factors, including occasional climatic variability, can have a strong impact on spatio-temporal patterns of infectious disease outbreaks.…”

Section: Introductionmentioning

confidence: 99%

The Intriguing Course of Coronavirus and its Age Dependent Variation in the Disease Outcome - A Concise Update

Swetha¹,

Ramasubramanian²,

Premavathy³

2020

ijrps

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Coronavirus is part of a family of enveloped positive-strand RNA viruses that infect mammals. COVID-19 pandemic which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] has affected hundreds of thousands of people worldwide with a rapid spreading and mutating strain of the virus. Morbidity and mortality of COVID-19 infections vary extensively from asymptomatic, mild to deadly and critical. Strangely, children were found to be protected from severe or deadly critical infections due to various reasons, on the other hand elderly with co-morbidities and immunocompromised adults were the most affected by this virus. Children with COVID-19 infection also present with similar symptoms as adults such as fever, dry cough, runny nose and nasal congestion, nausea, vomiting, diarrhoea, anosmia, abdominal pain and fatigue or may remain asymptomatic. Children have been found to harbour large amounts of virus and can probably transmit viruses even when they are asymptomatic hence can be a prominent carrier of the disease. Even though many studies have been conducted to ascertain the reasons for the differential consequences of the disease in adults and children, the present review was done to throw light and fill the gap on the age determined variations in the outcome of covid-19.

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A novel COVID-19 and its effects on cardiovascular disease

Cited by 78 publications

References 12 publications

Interplay of COVID-19 and cardiovascular diseases in Africa: an observational snapshot

Interplay of COVID-19 and cardiovascular diseases in Africa: an observational snapshot

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device

The Intriguing Course of Coronavirus and its Age Dependent Variation in the Disease Outcome - A Concise Update

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