A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Shen, Qiang; Jiang, Yansheng; Chen, Jing; Wang, Xueling; Zheng, Jiao

doi:10.1155/2021/8001787

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…The major limiting factor of curcumin medical applications is its low bioavailability. However, there is a new treatment formulation using dry powder inhalation of curcumin for COPD that can provide good solubility and dissolution [113]. There are several classes of polyphenols present in apple juice, including flavanols, dihydrochalcones, flavan-3-ols and phenolic acids.…”

Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyroptosis. There is currently intense interest in the role of nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes in chronic inflammatory lung diseases such as COPD and their potential for therapeutic targeting. Phytochemicals including polyphenols and flavonoids have phyto-medicinal benefits in CS-COPD. Here, we review published articles from the last decade regarding the known associations between inflammasome-mediated responses and ameliorations in pre-clinical manifestations of CS-COPD via polyphenol and flavonoid treatment, with a focus on the underlying mechanistic insights. This article will potentially assist the development of drugs for the prevention and therapy of COPD, particularly in cigarette smokers.

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Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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show abstract

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

mentioning

confidence: 99%

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

mentioning

confidence: 99%

Retracted: A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Applications¹

2023

Bioinorganic Chemistry and Applications

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Evaluation of the effects of curcumin on chronic obstructive pulmonary disease with a bio-computational approach

Maboudian,

Amjad,

Asnaashari

et al. 2024

Egypt J Med Hum Genet

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Background According to the increasing trend of COPD, the timely diagnosis and treatment of the disease can reduce the high costs to the health systems. Therefore, by biological calculation methods, signaling pathways and genes involved in this disease can be obtained and used to design drugs and other treatment methods. By using biological calculations, we determined that curcumin can affect this disease and its genes and signaling pathways. Our goal in this study was to find the genes by which curcumin exerts its effect and can maintain the function of corticosteroids against oxidizing agents. Results By finding the genes, it is possible to find precisely the pathways by which curcumin works, which can be used to design other drugs that cause these pathways and minimize their side effects. This study considers healthy samples (with/without curcumin) and oxygen-free radicals (with/without curcumin). Finally, statistical algorithms extract meaningful genes as effective biomarkers to investigate curcumin's effects and signaling pathways in COPD. The results show that the genes finally obtained as the most critical genes confirmed by the literature are effective in COPD. Finally, curcumin was input in SwissTargetPrediction to identify potential protein receptors. We used LigPlot+ software to visualize the receptor–ligand binding result provided by iGEMDOCK. Conclusions The data showed that the most significant genes in each group have been confirmed in other studies to be effective in this disease, and protein–protein interaction networks can be established between them to investigate their roles.

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A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Cited by 4 publications

References 41 publications

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Retracted: A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Evaluation of the effects of curcumin on chronic obstructive pulmonary disease with a bio-computational approach

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