A novel cyclohexenone from <i>Trachyspermum roxburghianum</i>

Wisetsai, Awat; Lekphrom, Ratsami; Schevenels, Florian

doi:10.1080/14786419.2017.1423299

Cited by 17 publications

(10 citation statements)

References 16 publications

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“…Exact structure: found in the roots of Angelica sinensis (AS) (Deng et al 2006), anti-inflammatory activity (Tran et al 2018), act as synergistic calcium antagonists for the treatment of coronary heart disease (Lei et al 2018), cytotoxic activity against MCF-7 (breast cancer), NCI-H187 (lung cancer) and KB cells (Wisetsai et al 2018), act as pancreatic lipase inhibitor for treatment of obesity (Mo et al 2016), used for the treatment of peptic ulcer (Chung et al 2005), used for the treatment and prevention of diabetes mellitus (D'orazio et al 2007)…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, compound s 1, 4, 5, 6, 7, 9, 10, 11, 12 possess anticancer activity against colon cancer cells, MCF-(breast cancer), NCI-H187 (lung cancer) and KB cells, human gastric cancer cells, HepG2 (Liver carcinoma) cells (Pagano et al 2017; Wisetsai et al 2018; Jung et al 2018; Ali et al 2001; Bigge et al 2003; Kuo et al 2016; Pelcman and Bengtsson 2018; Lee et al 2016; Hakonarson et al 2018) (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, some of the compounds identified also possess antidiabetic, anti-neurodegenerative, antioxidant, antiepileptic and anticancer activities (Bigge et al 2003; Wisetsai et al 2018; Gong et al 2016). Identified compounds contain furan, tyrosine, thione, albuterol, amines, curcumenol and pthalide moieties, potentially responsible for biological activities.…”

Section: Discussionmentioning

confidence: 99%

“…Curcumenol cpd 9, containing tetrahydrofuran is an active five-membered oxygen heterocyclic compound, commonly found in natural products, mainly responsible for their antibacterial activity (Keglevich 2015). Phthalides and fatty acids present in cpd 10 and 12 are also well known for their broad spectrum activities such as antiinflammatory, antimicrobial and anticancer activities (Bierer et al 1995; Gao et al 2013; Wisetsai et al 2018). Notably, 36 compounds were not identified in this study.…”

Section: Discussionmentioning

confidence: 99%

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Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity

et al. 2019

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The discovery of novel antimicrobials from animal species under pollution is an area untapped. Chinese red-headed centipede is one of the hardiest arthropod species commonly known for its therapeutic value in traditional Chinese medicine. Here we determined the antibacterial activity of haemolymph and tissue extracts of red-headed centipede, Scolopendra subspinipes against a panel of Gram-positive and Gram-negative bacteria. Lysates exhibited potent antibacterial activities against a broad range of bacteria tested. Chemical characterization of biologically active molecules was determined via liquid chromatography mass spectrometric analysis. From crude haemolymph extract, 12 compounds were identified including: (1) l -Homotyrosine, (2) 8-Acetoxy-4-acoren-3-one, (3) N -Undecylbenzenesulfonic acid, (4) 2-Dodecylbenzenesulfonic acid, (5) 3 H -1,2-Dithiole-3-thione, (6) Acetylenedicarboxylate, (7) Albuterol, (8) Tetradecylamine, (9) Curcumenol, (10) 3-Butylidene-7-hydroxyphthalide, (11) Oleoyl Ethanolamide and (12) Docosanedioic acid. Antimicrobial activities of the identified compounds were reported against Gram-positive and Gram-negative bacteria, fungi, viruses and parasites, that possibly explain centipede’s survival in harsh and polluted environments. Further research in characterization, molecular mechanism of action and in vivo testing of active molecules is needed for the development of novel antibacterials.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity

et al. 2019

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“…3-butylidene-7-hydroxyphthalide identified from conditioned media HSG16 has previously reported anticancer activity; it exhibited cytotoxicity against breast cancer MCF-7 cells [ 35 ]. While these identified molecules had reported anticancer activity, the other detected molecules had a broad range of reported biological activities: citric acid, dextromethorphan and 3-butylidene-7-hydroxyphthalide had reported antibacterial activity [ 36 , 37 , 38 , 39 , 40 ]. U-0126, 3-hydroxymorphinan and bifemelane exhibited neuroprotective effects [ 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules

Soopramanien

Khan

Ghimire

et al. 2020

Biology

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Despite intensive research, cancer incidence and mortality continue to rise. Consequently, the necessity to develop effective anti-cancer therapy is apparent. We have recently shown that the gut bacteria of animals living in polluted environments, such as crocodiles, are a potential source of novel anti-tumor molecules. To extend this work to other resilient species, we investigated the anti-tumor effects of gut bacteria of Heterometrus spinifer (a scorpion). Bacteria from the feces and gut were isolated, identified and evaluated for their anti-tumor effects. Bacterial-conditioned media was prepared in Roswell Park Memorial Institute (RPMI) 1640 media, and cytotoxicity and growth inhibitory properties were examined against cervical (HeLa) cancer cells. Liquid chromatography–mass spectrometry (LC-MS) was conducted to establish the identity of the molecules. Eighteen bacteria species from the gut (HSG01-18) and ten bacteria species from feces (HSF01-10) were tested for anti-tumor effects. Bacterial-conditioned media from scorpion gut and feces exhibited significant growth inhibitory effects against HeLa cells of 66.9% and 83.8%, respectively. Microscopic analysis of cancer cells treated with conditioned media HSG12 and HSG16 revealed apoptosis-like effects. HSG12 was identified as Pseudomonas aeruginosa and HSG16 was identified as Bacillus subtilis. Both conditioned media exhibited 100% growth inhibitory effects versus a selection of cancer cells, comprising cervical, breast and prostate cancer cells. LC–MS indicated the presence of 72 and 38 compounds, detected from HSG12 and HSG16, respectively. Out of these compounds, 47 were successfully identified while the remainder were unidentified and are possibly novel. This study suggests that the fecal and gut microbiota of scorpions might possess molecules with anti-cancer properties, however, further intensive research is needed to assess these expectations.

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