A novel delivery of curcumin by the efficient nanoliposomal approach against <i>Leishmania major</i>

Bafghi, Ali Fattahi; Haghiralsadat, Bibi Fatemeh; Yazdian, Fatemeh; Mirzaei, Farzaneh; Pourmadadi, Mehrab; Pournasir, Fahimeh; Hemati, Mahdie; Pournasir, Soheila

doi:10.1080/10826068.2021.1885045

Cited by 39 publications

(13 citation statements)

References 25 publications

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“…Fattahi Bafghi et al loaded curcumin onto nanoliposomes by thin-film hydration to assess its anti-leishmanial effects on L. major . The recorded concentrations of nanocomposite that killed 50% of the promastigote population were 6.41, 3.8 and 2.33 μg/ml at 24, 48 and 72 h, respectively, which had a better effect than the control drug amphotericin B in all conditions ( 13 ).…”

Section: Resultsmentioning

confidence: 98%

Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis: An Evidence-Based Review

Alanazi¹,

Saïd²

2022

IJPA

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Background: This study was designed considering the challenges of leishmaniasis treatment and the benefits of carriers of drug delivery systems to review plant bioactive ingredients in delivery systems and nanocarriers for the treatment of leishmaniasis. Methods: The methodology of this review investigation followed the 06-PRISMA recommendations. The searches were carried out up to January 30, 2022, in the central English databases SCOPUS, WEB OF SCIENCE, EMBASE, PUBMED, and GOOGLE SCHOLAR using the search terms “ç”, “leishmaniasis”, “herbal medicines”, “drug delivery”, “nanocarriers”, “herbal compounds”, and “secondary metabolites”. Results: Out of 5731 articles, 19 publications, including 12 in vivo (63.15%), 3 in vitro (15.8%), and 4 in vitro/ in vivo (21.1%) up to 2022, fulfilled the criteria presence for argument in the current systematic study. Plant bioactive ingredients were curcumin, betulinic acid, artemisinin, 4-nitrobenzaldehyde thiosemicarbazone, andrographolide, pentalinonsterol, ursolic acid, amarogentin, carvacrol, 14-deoxy-11-oxo-andrographolide, quercetin, beta-lapachone, cedrol, 2ˊ,6ˊ-dihydroxy-4ˊ-methoxychalcone, and oleanolic acid. Conclusion: The high potential of plant bioactive ingredients in delivery systems due to the load on the nanocarrier for the treatment of leishmaniasis through some main mechanisms of action, e.g. changes in the fluidity and the structure of the cell wall, creation of reactive oxygen species (ROS) and mitochondrial dysfunction, inhibition of DNA topoisomerase I enzyme, minimal cytotoxicity, stimulation of cell cycle disruption, stimulation of apoptosis, enhancement of the immune system. However, further investigations, especially in the clinical setting, are required to confirm these findings.

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Section: Resultsmentioning

confidence: 98%

Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis: An Evidence-Based Review

Alanazi¹,

Saïd²

2022

IJPA

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“…The first peak corresponds to the enolic form and the second to the ketonic form. [ 76–78 ] These findings suggest that the free drug could not escape from the nanocarrier. Additionally, the receptor solution was never significantly tinted, even after the completion of the experiment.…”

Section: Resultsmentioning

confidence: 99%

Mixed Hyperbranched/Triblock Copolymer Micelle Assemblies: Physicochemical Properties and Potential for Drug Encapsulation

Gerardos

Balafouti

Pispas

2023

Macro Chemistry & Physics

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Mixed micelles have numerous advantages while requiring little to no effort in preparation. This study aims to produce mixed micelle nanostructures from a linear triblock copolymer and a hyperbranched random copolymer, and is able to be loaded with the weakly water‐soluble drugs curcumin and indomethacin. Different preparation techniques are employed to produce mixed micelles comprised of Pluronic F127 block copolymer, and hyperbranched poly[(ethylene glycol) methyl ether methacrylate‐co‐lauryl methacrylate], H‐[P(OEGMA‐co‐LMA)], copolymer. Few studies have dabbled in these types of coassemblies, which provides insight into how structural differences of each copolymer can affect the formation of micelles. To determine the properties of the emerging nanostructures in aqueous environments, including their size, homogeneity, and surface charge, different physicochemical techniques are used, such as light scattering and spectroscopic methods. The results reveal that the copolymers combine, and spontaneously self‐assemble into mixed micelle‐like nanostructures in aqueous environments, whereas both systems of neat and drug‐loaded nanostructures exhibit desirable properties such as small average micelle hydrodynamic radii and low size polydispersity indices. The nanostructures that result from the effective encapsulation of curcumin exhibit outstanding stability over 169 days. The fluorescent qualities of curcumin persist after encapsulation, making the novel nanostructures excellent candidates for bioimaging applications.

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“…Based on the different components and their applicability as drug carriers, different approaches for using MOFs as antimicrobial agents have been reported. [ 163–168 ] Their metallic sites or organic bridges can display antimicrobial activity. Also, they can be loaded with antimicrobial agents and release their cargo on site.…”

Section: Antimicrobial Activity Of Drug‐loaded Mofsmentioning

confidence: 99%

“…It is noteworthy that the coordination bond responsible for loading of drugs on MOFs is often pH‐responsive. [ 163–168 ]…”

Section: Antimicrobial Activity Of Drug‐loaded Mofsmentioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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Recently, metal-organic frameworks (MOFs) have received a lot of interest for application in many fields ranging from catalysis, energy storage, and gas sensing to chemosensory and biomedicine owed to their flexible composition, tunable porosity, and easy functionalization ability. In particular, nanoscale MOFs have been broadly investigated as carriers for the delivery of therapeutics to cancerous organs owed to their high encapsulating capacity and controlled cargo release, versatility, biodegradability, and good biocompatibility.Several methods such as solvothermal, mechanochemical, electrochemical, microwave, and ultrasound have been utilized to fabricate MOFs via custommade synthesis. Many efforts have been made to functionalize MOFs through "post-synthetic modification," by adjusting the nature, size, and charge of the linkers or tuning its main components. Herein, a comprehensive literature review on recent papers dealing with drug-loaded MOFs for the detection and treatment of cancer as well as bacterial, fungal, and viral infections is presented. Different types of MOFs applied as carriers in drug delivery systems and biosensing platforms are described. Furthermore, perspectives and challenges for future research in the field, particularly for cancer therapy, are discussed. Thus, very limited literature is available on in vitro and in vivo toxicity of nanoscale MOFs. Besides, their biological stability and long-term safety are crucial factors that should be further investigated. Based on the reviewed papers, zeolite imidazolate framework (ZIF) and Materials of Institute Lavoisier (MIL) families have been the main focus for drug delivery and diagnosis applications, respectively, while many types of MOFs have exhibited antibacterial and antifungal properties regardless of their cargo.

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A novel delivery of curcumin by the efficient nanoliposomal approach against Leishmania major

Cited by 39 publications

References 25 publications

Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis: An Evidence-Based Review

Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis: An Evidence-Based Review

Mixed Hyperbranched/Triblock Copolymer Micelle Assemblies: Physicochemical Properties and Potential for Drug Encapsulation

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

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