A Novel Delivery System of Probiotic Drop and Its Effect on Dental Caries Risk Factors in Cleft Lip/Palate Children

Çıldır, Şule Kavaloğlu; Sandallı, Nüket; Nazli, Serpil; Alp, Fatos; Çağlar, Eşber

doi:10.1597/10-035

Cited by 31 publications

(20 citation statements)

References 32 publications

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“…This may partly explain the discrepancy between our current results and those of earlier studies. Recently, a study by Cildir et al demonstrated that one daily dose of L. reuteri fails to reduce the salivary MS counts in children [23]. More research is clearly needed on this topic.…”

Section: Discussionmentioning

confidence: 99%

Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque

et al. 2011

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Acidogenicity and the levels of mutans streptococci (MS) in dental plaque after the use of Lactobacillus rhamnosus GG (LGG) and Lactobacillus reuteri were determined. The study had a randomised, double-blind, crossover design. Thirteen volunteers used tablets containing LGG or a combination of L. reuteri SD2112 and PTA 5289 for 2 weeks. At baseline and at the end of each tablet period, all available supragingival plaque was collected. Lactic acid production was determined from a fixed volume (8 μl) of fresh plaque and the rest of the plaque was used for culturing MS and lactobacilli. The retention of probiotics to the plaque was assessed using PCR techniques. No probiotic-induced changes were found in the acidogenicity of plaque. Also, MS counts remained at the original level. The number of subjects with lactobacilli in plaque increased in the L. reuteri group (p = 0.011) but not in the LGG group. PCR analysis of plaque revealed the presence of LGG in four and L. reuteri in six subjects after the use of the probiotic. The use of the lactobacilli did not affect the acidogenicity or MS levels of plaque. Short-term consumption of LGG and L. reuteri appeared not to influence the acidogenicity of plaque.

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Section: Discussionmentioning

confidence: 99%

Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque

et al. 2011

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“…This inconsistency may be due to the numerous strains investigated or differences in study design and/or study population [Näse et al, 2002;Cildir et al, 2009;Stecksén-Blicks et al, 2009;Lexner et al, 2010;Jindal et al, 2011;Singh et al, 2011;Cildir et al, 2012]. Certain naturally occurring LBC inhibit the growth of a patient's autologous MS in vitro.…”

mentioning

confidence: 99%

Early Intervention with Probiotic <b><i>Lactobacillus paracasei </i></b>F19 Has No Long-Term Effect on Caries Experience

Hasslöf¹,

West

Videhult

et al. 2013

Caries Res

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The aim of the study was to evaluate possible long-term effects of a cereal diet supplemented with Lactobacillus paracasei F19 (LF19) during weaning on caries experience, mutans streptococci (MS) and lactobacilli (LBC) in a group of 9-year-old children. A secondary aim was to evaluate if the intervention resulted in the permanent integration of LF19 as part of the oral microbiota. The study followed up on a double-blind placebo-controlled randomised trial. Among 179 infants that were randomised to a daily diet that included cereals with or without LF19 from 4 to 13 months of age, 56 from the probiotic group and 62 from the placebo group participated in the follow-up at 9 years. Data were collected by oral clinical examination and questionnaires. MS and LBC levels were assessed with conventional cultivation; LF19 was detected by using randomly amplified polymerase chain reactions (RAPD-PCR). At the follow-up, neither decayed, missing and filled surfaces for primary teeth (dmfs) nor decayed, missing and filled surfaces for permanent teeth (DMFS) differed significantly between the probiotic and placebo groups (p > 0.05). MS and LBC levels were similar in both groups (p > 0.05). RAPD-PCR showed no evidence of oral colonisation with LF19 in the study group. It is concluded that an early intervention with LF19 did not affect the frequency of dental caries, MS or LBC. LF19 did not establish itself as a permanent facet of the oral microbiota in any of the subjects included in this study.

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“…[256719] However, some other studies have not shown any difference in SM counts. [8121320] Several studies have shown a relationship between dental caries and SM counts. [21] It is very difficult to compare the results of studies because of different study designs, duration of intervention, the parameters evaluated, and the type of probiotics used, combination of different species, and their vehicles.…”

Section: Discussionmentioning

confidence: 99%

“…[891011] Two studies have been carried out with the use of drops containing Lactobacillus reuteri and no differences have been observed between salivary counts of Lactobacillus (LB) and SM. [1213] Regarding the conflicting results of previous studies about the effects of probiotic products on oral health and as well as the importance of oral health, this study was performed. [14]…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotic drop containing Lactobacillus rhamnosus, Bifidobacterium infantis, and Lactobacillus reuteri on salivary Streptococcus mutans and Lactobacillus levels

et al. 2016

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Aims:The aim of the present study was to evaluate the effect of a probiotic drop containing Lactobacillus rhamnosus, Bifidobacterium infantis, and Lactobacillus reuteri on salivary counts of Streptococcus mutans (SM) and Lactobacillus (LB) in children 3–6 years of age.Settings and Design:Sixty-one healthy children were randomly allocated into two parallel blocks in this double-blind, randomized controlled trial (IRCT2014120320202N1) from May to June 2015.Subjects and Methods:Finally 53 participants consumed five drops of placebo (n = 23) or probiotic (n = 30) every night for 2 weeks. Before intervention and 1 day after completion of the intervention, unstimulated salivary samples were collected, and microbiologic evaluations were carried out.Statistical Analysis:Data were analyzed with descriptive statistical methods Wilcoxon signed ranks, Mann–Whitney, and logistic regression.Results:SM level decreased significantly in probiotic group after intervention (P = 0.045), and there were significant differences in salivary SM counts after intervention between two groups (P = 0.04). In probiotic group, LB counts decreased significantly after intervention (P = 0.048); however, there were no significant differences between two groups (P = 0.216).Conclusions:Use of this probiotic drop decreased salivary counts of SM; however, LB counts did not change. In addition, use of the drop in children with higher salivary counts appeared to be more effective.

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A Novel Delivery System of Probiotic Drop and Its Effect on Dental Caries Risk Factors in Cleft Lip/Palate Children

Abstract: The novel drop containing L. reuteri may not reduce the levels of salivary mutans streptococci and lactobacilli in cleft lip/palate children.

Cited by 31 publications

References 32 publications

Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque

Short-term consumption of probiotic lactobacilli has no effect on acid production of supragingival plaque

Early Intervention with Probiotic <b><i>Lactobacillus paracasei </i></b>F19 Has No Long-Term Effect on Caries Experience

Effects of probiotic drop containing Lactobacillus rhamnosus, Bifidobacterium infantis, and Lactobacillus reuteri on salivary Streptococcus mutans and Lactobacillus levels

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