A Novel Derivatization Method for Separation of Sarcosine from Isobaric l-Alanine in Human Urine by GC–MS

Sarcosine was recently identified as a differential metabolite that is present in urine in elevated concentration as prostate cancer develops metastases. The aim of this study is to prepare reflectometric interference spectroscopy (RIfS) nanosensors for the detection of sarcosine. Sarcosine imprinted nanoparticles were prepared by two phase miniemulsion polymerization and characterized with transmission electron microscopy, dynamic light scattering, and atomic force microscopy measurements. The glass substrates (10 3 10 mm 2 ) were treated with Piranha solution and incubated in polyethyleneimine solution. The sarcosine imprinted nanoparticles were attached to glass substrates by spin coating of nanoparticle solution. The recognition properties of the nanosensors were evaluated by reflectometric interferometric spectroscopy. To show selectivity of sarcosine imprinted RIfS nanosensor, real-time L-alanine detection was also performed. Sarcosine detection studies were performed from aqueous solution and urine sample. A good linearity was revealed with a correlation coefficient of 0.9622 and a detection limit of 45 nM.

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A reflectometric interferometric nanosensor for sarcosine

Di̇ltemi̇z

Uslu

2015

Biotechnology Progress

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A Novel Derivatization Method for the Determination of Saisentong in Soil by High-Performance Liquid Chromatography

Meng

et al. 2014

Chromatographia

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Metal-coded hydrogel magnetic molecularly imprinted polymer for preconcentration and cleanup of sarcosine: Determination in urine; coupled to on-column capillary electrophoresis

Ramezani

Safdarian

Ghadiri

2021

Talanta

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A Novel Derivatization Method for Separation of Sarcosine from Isobaric l-Alanine in Human Urine by GC–MS

Cited by 5 publications

References 21 publications

A reflectometric interferometric nanosensor for sarcosine

A reflectometric interferometric nanosensor for sarcosine

A Novel Derivatization Method for the Determination of Saisentong in Soil by High-Performance Liquid Chromatography

Metal-coded hydrogel magnetic molecularly imprinted polymer for preconcentration and cleanup of sarcosine: Determination in urine; coupled to on-column capillary electrophoresis

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