A one-dimensional mathematical model is developed to evaluate the operating and design parameters of the desiccant wheel for air conditioning application. In this paper, dehumidification coefficient of performance (DCOP) and sensible energy ratio (SER) are adopted as a combined performance index to reflect the dehumidification and thermal performance of the desiccant wheel. The analysis of the results reveals that for lower SER, suitable wheel length, wall thickness, channel pitch, and channel height should be 100 mm, 0.2 mm, 3 mm, and 5 mm, respectively. These design parameters have been analyzed under different operating conditions and it was found that for higher DCOP, rotational speed, regeneration temperature, process and regeneration velocity should be 20 rph, 60 • C, and 2 m/s. K E Y W O R D S DCOP, design parameters, operating parameters, sensible energy ratio Nomenclature: , channel height (m); csdl , cross-sectional area of the desiccant layer (m 2 ); csf , [m 2 ] cross sectional area of flow passage of one channel; , [m] pitch of the channel; p , (J/kg K) specific heat at constant pressure; c pw , (J/kg K) specific heat of liquid water; pm , (J/kg K) specific heat of substrate (matrix material); D, [m] diameter of desiccant wheel; ℎ fg , [J/kg] latent heat of vaporization; ℎ m , [kg/m 2 s] mass transfer coefficient;ℎ, [W/m 2 K] convective heat transfer coefficient; , [W/m K] thermal conductivity; , [m] wheel length; MR, [kg kg −1 ] moisture removal; [Pa], pressure; f , [m] perimeter of the flow passage of one channel; , [Pa] pressure drop; ad , [J/kg adsorbate] heat of adsorption; , [Sec] time; , [K] temperature; , [m/s] velocity; , [kg adsorbate kg adsorbent −1 ] water content in desiccant; , axial direction; , [kg kg −1 ] humidity ratio of the air Greek symbols: , [kg/m 3 ]