2023
DOI: 10.1111/1744-9987.13989
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A novel device and system concept for therapeutic plasma exchange in rats

Abstract: Introduction: Therapeutic plasma exchange (TPE) has been developed more than 100 years ago in an animal model and adapted to humans 30 years later.Since then, the TPE research on animal models is lacking, mainly due to difficulties raised by the scaling of the plasmapheresis unit so that the animal's cardiovascular parameters are not considerably affected. Methods: The system concept of a novel TPE device with continuous hemodynamic monitoring in small rodent models has been used.Results: A continuum TPE unit … Show more

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