A novel device for ablation of abnormal esophageal mucosa (with video)

Friedland, Shai; Triadafilopoulos, George

doi:10.1016/j.gie.2011.03.1119

Cited by 25 publications

(20 citation statements)

References 20 publications

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“…1E and G). All patients underwent at least 1 cryoablation procedure (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The total number of cryoablation procedures for the intention-to-treat cohort was 117, with a technical success rate of 115 of 117 (98%) because of 2 incomplete cryoablation treatments (2 patients) related to balloon migration from a pre-existing stricture.…”

Section: Resultsmentioning

confidence: 99%

“…for esophageal mucosal ablation. 11 The CbFAS consists of a small hand-held device containing liquid nitrous oxide in a capsule ( Fig. 1D) that converts to gas within a single-use low-pressure compliant balloon 11 ( Fig.…”

Section: Footnotes Appear On Last Page Of Article)mentioning

confidence: 99%

“…1A and C). The cryogen makes contact with the balloon and freezes targeted mucosa to -85 C. 11 Rotation of the diffuser within the balloon, which is actuated by tilting the handle of the device, enables targeting of specific areas of BE (Video 1, available online at www.giejournal.org).…”

Section: Footnotes Appear On Last Page Of Article)mentioning

confidence: 99%

“…12 Prior animal dosing experiments using squamous-lined porcine esophagus showed varying degrees of submucosal edema and inflammation and patchy edema, inflammation, and injury but not necrosis in the muscularis propria with a 10-second cryoablation. 11 The 3.7-mm focal cryoballoon catheter was passed through a standard or high-definition therapeutic channel videoendoscope or placed through an accessory "side car" (Fig. 1B) attached a standard high-definition endoscope.…”

Section: Endoscopic Proceduresmentioning

confidence: 99%

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Multifocal nitrous oxide cryoballoon ablation with or without EMR for treatment of neoplastic Barrett’s esophagus (with video)

Canto

Shaheen

Almario

et al. 2018

Gastrointestinal Endoscopy

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Section: Resultsmentioning

confidence: 99%

Section: Footnotes Appear On Last Page Of Article)mentioning

confidence: 99%

Section: Footnotes Appear On Last Page Of Article)mentioning

confidence: 99%

Section: Endoscopic Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

Multifocal nitrous oxide cryoballoon ablation with or without EMR for treatment of neoplastic Barrett’s esophagus (with video)

Canto

Shaheen

Almario

et al. 2018

Gastrointestinal Endoscopy

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“…[13][14][15] Since a consistent ablation effect with a spray catheter may be difficult to achieve, a new way of cryoablation has recently been developed: the balloon-based circumferential CryoBalloon Ablation System (CBAS; C2 Therapeutics, Redwood City, CA, USA). 16,17 In contrast to the HALO360 catheter, the balloon of the CBAS is compliant and has the ability to adjust to strictures which may enable ablation of Barrett's mucosa within a stenosis.…”

Section: Introductionmentioning

confidence: 99%

Circumferential cryoablation in a strictured esophagus: a feasibility and dose-finding study in a porcine model after inducing stenosis by endoscopic mucosal resection

et al. 2015

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In the treatment of early esophageal Barrett's neoplasia, radiofrequency ablation may be hindered by stenosis due to prior endoscopic resection (ER). The flexible balloon-based circumferential CryoBalloon Ablation System (CBAS) may overcome this problem by the conformability of the compliant balloon which might enable circumferential cryoablation in a stenosis. The aim of the current study was to evaluate the feasibility of the CBAS as well as the dose-response effect of cryoablation in a strictured esophagus model. In six pigs, a stenosis was induced by ER (3 cm in length, 75% of circumference) in the proximal, mid, and distal esophagus. After 28 days, cryoablation with the CBAS was performed, with the length of ablation time (6, 8, or 10 seconds) randomly assigned per stricture location within the esophagus. Four days post-ablation, the esophagi were harvested for histopathological assessment of the percentage of the total circumference affected by cryoablation and the maximum depth of necrosis. At 28 days, all 18 ER areas had transformed into strictures with ±50% of its original diameter remaining. In 9 of 18 strictures, more than one attempt for cryoablation was necessary due to displacement of the balloon. Histopathological evaluation showed a wide range in circumferential uniformity (0-100%) and maximum necrosis depth (epithelium to external proper muscle layer) of cryoablation, both independent of ablation times. Deepest ablation effects were seen at the center of the resection-induced scar. This first generation CryoBalloon Focal Ablation System was not feasible for ablation within severe stenoses, since it results in inconsistent circumferential uniformity of cryoablation with subsequent differences in depth of ablation. Further research with a next generation CBAS in a more realistic stricture model is warranted.

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