A Novel ECMO Circuit Using a SYNERGY Circulite Pump in a Swine Model

Abstract

Extracorporeal membrane oxygenation (ECMO) is used in the management of refractory cardiopulmonary failure. With improvements in technology, patients can be transferred between hospitals, ambulated, and supported for extended periods of time while on ECMO. The SYNERGY CircuLite micropump is a blood pump that has been used as a ventricular assist device for partial support. In this study, we assessed the blood biocompatibility of the SYNERGY blood pump in conjunction with a Quadrox D oxygenator for use in a novel ECMO circuit in a swine model. This clinical design was used to demonstrate early feasibility of this pump system. Four pigs were placed on venovenous ECMO circuit, which consisted of a SYNERGY pump, Quadrox D oxygenator, and Cobe E Pack 3/8 inch tubing. All animals survived the 6 hour ECMO run without catastrophic biocompatibility issues. There was no statistically discernible change from baseline in hematologic parameters, including hemoglobin, plasma-free hemoglobin, total bilirubin, lactate dehydrogenase, D-dimer, fibrinogen, platelets, and P-selectin. We believe that this study serves as a proof of concept and basis for further studies using the SYNERGY pump as a component of ECMO systems.

Hemodynamic investigation of a novel rotary displacement blood pump for extracorporeal membrane oxygenation

“…As one of the core components of ECMO, a blood pump has a considerable impact on the therapeutic effect and development of ECMO. 3,4 Centrifugal pump delivers fluid through the centrifugal force generated by the high-speed rotation of the impeller with the ability to generate high flow at low pressure; patients can be conveniently transferred during extracorporeal life support (ECLS) owing to the small size of this pump. 5,6 Therefore, centrifugal pumps are conventionally used in recent years in clinics because of their simplicity and portability.…”

“…ECMO supports cardiac output and oxygenation through a blood pump to achieve circulating flow. As one of the core components of ECMO, a blood pump has a considerable impact on the therapeutic effect and development of ECMO 3,4 …”