A novel electrochemical biomimetic sensor based on E-MIP artificial acceptor and SI-ATRP assisted signal amplification

Electroanalytical overview: The electroanalytical detection of theophylline

“…A slight drawback is that each concentration being measured takes 13 mins for binding to occur. The sensor was demonstrated to exhibit a high selectivity towards theophylline, which was attributed by the authors to the polymer film possessing robust imprinted sites/cavities that preserved precisely the memory of the shape, size, and conformation of the template molecule theophylline [30] .…”

“…Molecularly imprinted polymers (MIPs) have been utilised in sensing platforms as biomimetic recognition elements for a wide range of analytical targets [23] and it is therefore no surprise that MIPs have been explored for theophylline [24][25][26][27][28][29][30] . For example, Kindschy and Alocilja discribed the development of a MIP that was highly selective to theophylline over caffeine but with a poor detection range (mM) [25] .…”

“…For example, Kindschy and Alocilja discribed the development of a MIP that was highly selective to theophylline over caffeine but with a poor detection range (mM) [25] . Of note, Zhang et al [30] reported a biomimetic sensor for theophylline detection, which is summarised in Fig. 2 .…”

“…Note that the therapeutic window of theophylline is 10-20 μg/mL (55.5-111 μM) (see text). 11 pM [30] in model solutions. A slight drawback is that each concentration being measured takes 13 mins for binding to occur.…”