A novel electrochemical sensor based on electropolymerized molecularly imprinted polymer and gold nanomaterials amplification for estradiol detection

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

“…Benefiting from the unique physical and chemical properties, MIPs with high selectivity and affinity have been widely used as the biological sensing elements in electrochemical sensors (Jin et al, 2011;Kong et al, 2013;Wang et al, 2015;Zhang et al, 2014). However, owing to the highly cross-linked characteristics of imprinted polymer, the electron transfer and the diffusion of analyte to the recognition site are both obstructed in a particular degree, which leads to a decrease in the detection efficiency and accuracy (Lakshmi et al, 2009).…”

Electrochemical sensor for the detection of estradiol based on electropolymerized molecularly imprinted polythioaniline film with signal amplification using gold nanoparticles

“…MIPs have several advantages, over biological molecules, such as simple synthesis, low cost, high selectivity, mechanical strength and resistance at various temperatures and pH [10]. Zhang et al reported on an electrochemical sensor based on electropolymerized MIP with electrodeposited AuNP amplification for the detection of 17β-estradiolin milk samples that exhibited a detection limit of 1.28 × 10 −12 mg/mL [11]. In another approach Yuan's group fabricated an MIP sensor for 17β-estradiol based on the electropolymerization of 6-mercaptonicotinic acid on Pt nanoparticles-modified electrode.…”

Recent developments in recognition elements for chemical sensors and biosensors

“…After the removal of template molecules, chemically-selective recognition sites (in active sites or cavities) are created in the cross-linked polymer matrix and are complementary in shape, size and functional group to the template molecules [31,34]. Thus, MIPs are specific in terms of geometry, and electrostatic and hydrophobic chemical interactions with target molecules, with binding specificity similar to that of typical antibody-antigen interactions [11].…”