Performance-based seismic design methods for bridges are advancing, yet limited research has explored the damage mechanisms of bridges subjected to extreme seismic effects, such as those near or across faults. To investigate the damage mechanisms under bedrock dislocation and bridge rupture resistance, providing essential insights for the standardized design and construction of bridges in close proximity to seismic rupture sites, we developed a large-scale device to model bridges in the immediate vicinity of tilted-slip strong seismic rupture sites. This included a synchronous bedrock dislocation loading system. Four sets of typical sandy soil modeling tests were concurrently conducted. The results indicate: (1) The overall shear deformation zone of the foundation and surface uneven deformation primarily concentrate the overburdened soil body along the fault dip. The damaged area under the low-dip reverse fault is lighter on the surface and inside the soil body compared to the high-dip-positive fault. (2) The presence of bridges reduces the width of the main rupture zone and avoidance distance to some extent. However, this reduction is not as significant as anticipated. The damage to the bridge pile foundation along the fault dislocation tendency notably leads to the bending damage of the bridge deck. (3) Input parameters for fracture-resistant bridge design (surface rupture zone location, extent, maximum deformation, etc.) can be deduced from the free site. Within the rupture zone, a “fuse” design can be implemented using simply supported girders. Additionally, combining the “fuse” design with simple supported girders on both sides and utilizing simple support beams for “fuse” design within the rupture zone, along with structural “disconnection”, allows for reinforcing measures on the bridge structure’s foundation platform and pile in the soil body.