A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans

Jensen, Gitte S.; Patel, Dilip; Benson, Kathleen F.

doi:10.1016/j.ypmed.2012.01.004

Cited by 28 publications

(24 citation statements)

References 25 publications

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“…When the cow is infected by pathogens, the level of CD59 drops and therefore its inhibitory role in the complement system will be reduced, thereby allowing the complement system to function during the inflammation [ 39 ]. The high abundance of complement proteins indicates that colostrum not only confers components from the adaptive immune system to the newborns but that it also transfers proteins of the innate immune system [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

et al. 2015

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In order to better understand the milk proteome and its changes from colostrum to mature milk, samples taken at seven time points in the first 9 days from 4 individual cows were analyzed using proteomic techniques. Both the similarity in changes from day 0 to day 9 in the quantitative milk proteome, and the differences in specific protein abundance, were observed among four cows. One third of the quantified proteins showed a significant decrease in concentration over the first 9 days after calving, especially in the immune proteins (as much as 40 fold). Three relative high abundant enzymes (XDH, LPL, and RNASE1) and cell division and proliferation protein (CREG1) may be involved in the maturation of the gastro-intestinal tract. In addition, high correlations between proteins involved in complement and blood coagulation cascades illustrates the complex nature of biological interrelationships between milk proteins. The linear decrease of protease inhibitors and proteins involved in innate and adaptive immune system implies a protective role for protease inhibitor against degradation. In conclusion, the results found in this study not only improve our understanding of the role of colostrum in both host defense and development of the newborn calf but also provides guidance for the improvement of infant formula through better understanding of the complex interactions between milk proteins.

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Section: Discussionmentioning

confidence: 99%

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

et al. 2015

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“…This suggests that apart from a minor population of whey‐specific T cells also aspecific or bystander T cell activation was caused by whey. Intrinsic capacities of the whey protein fraction may contribute to this . Since percentages of both activated Th1 and Th2 cells were reduced by the fish oil diet in sham mice this suggests a general suppression of immune activation by the fish oil diet.…”

Section: Discussionmentioning

confidence: 99%

Dietary long chain n‐3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice

Elsen

Esch

Hofman

et al. 2013

Clin Experimental Allergy

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“…These contradictory results may be attributable to the use of test subjects with good health and nutritional status and without exercise-induced immune perturbation. In a recent single-dose crossover RT, Jensen et al 46 tested the effect of a low-molecular-weight immunoglobulin-depleted fraction of bovine colostrum or a rice flour placebo in 12 healthy subjects, finding increased phagocytic activity of monocytes and polymorphonuclear cells, an increased white blood cell count, and a transient decrease in the circulation of natural killer cells, while Appukutty et al 72 found modulated in vitro interferon-γ activity after 6 weeks of colostrum supplementation in adolescent athletes. These results suggest that bovine colostrum may, after contact with the gut mucosa, trigger immunological events that are followed by systemic effects.…”

Section: Infection and Immune Responsesmentioning

confidence: 99%

Clinical applications of bovine colostrum therapy: a systematic review

et al. 2014

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Bovine colostrum, the first milk that cows produce after parturition, contains high levels of growth factors and immunomodulatory components. Some healthy and diseased individuals may gain health benefits by consuming bovine colostrum as a food supplement. This review provides a systematic, critical evaluation of the current state of knowledge in this area. Fifty‐one eligible studies were identified from the following databases: Medline, Embase, Global Health, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature. Studies were heterogeneous with regard to populations, outcomes, and methodological quality, as judged by the Jadad assessment tool. Many studies used surrogate markers to study the effects of bovine colostrum. Studies suggesting clinical benefits of colostrum supplementation were generally of poor methodological quality, and results could not be confirmed by other investigators. Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application. Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing these effects in humans.

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A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans

Cited by 28 publications

References 25 publications

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

Dietary long chain n‐3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice

Clinical applications of bovine colostrum therapy: a systematic review

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