2016
DOI: 10.1002/ptr.5680
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A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double‐Blind, Placebo‐Controlled Study

Abstract: Despite the widespread use of hormone replacement therapy, various reports on its side effects have generated an increasing interest in the development of safe natural agents for the management of postmenopausal discomforts. The present randomized, double-blinded, placebo-controlled study investigated the effect of 90-day supplementation of a standardized extract of fenugreek (Trigonella foenum-graecum) (FenuSMART™), at a dose of 1000 mg/day, on plasma estrogens and postmenopausal discomforts. Eighty-eight wom… Show more

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Cited by 42 publications
(24 citation statements)
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“…Acute (14 days), and sub-chronic (90-days) toxicity studies were carried out along with the Ames test for mutagenicity. Despite the toxicity studies of various extracts of fenugreek seeds [ [23] , [24] , [25] ], the significance of the present study lies in the fact that the unique composition of various phytochemicals in ‘FHE’ was shown to possess significant efficacy in ameliorating the postmenopausal discomforts and helps to establish the hormone balance [ 26 ].…”
Section: Introductionmentioning
confidence: 99%
“…Acute (14 days), and sub-chronic (90-days) toxicity studies were carried out along with the Ames test for mutagenicity. Despite the toxicity studies of various extracts of fenugreek seeds [ [23] , [24] , [25] ], the significance of the present study lies in the fact that the unique composition of various phytochemicals in ‘FHE’ was shown to possess significant efficacy in ameliorating the postmenopausal discomforts and helps to establish the hormone balance [ 26 ].…”
Section: Introductionmentioning
confidence: 99%
“…Of these, 330 were excluded; 59 included fewer than 20 women per study arm and 54 were not an RCT; 126 did not clearly state a sample size calculation; 52 did not measure vasomotor symptoms as the primary outcome; 39 were secondary analysis. Following these exclusions, 214 RCT were included…”
Section: Resultsmentioning
confidence: 99%
“…A trial 8 assessed the effect of fenugreek husk to manage the insomnia. In this study, 88 menopausal women were divided equally into 2 groups of fenugreek husk (n = 44) and placebo (44).…”
Section: Resultsmentioning
confidence: 99%