As the power interface between the energy storage devices (ESD) and the dc link of DC Micro-grids, dc-dc converters, which have been regarded as the heart of many critical applications such as electrical vehicles, data center, and aerospace power systems, have gained more and more attentions recently. The fault diagnosis and tolerant control in dc-dc converters become essential to ensure a reliable and robust power system especially for critical applicants, where a sudden stoppage, loss of functionality, or degradation of performance might result in a catastrophe. This paper focuses on different types of faults in dc-dc converters by analyzing main failure spots and mechanism, covering catastrophic fault and parametric fault from component to system. A comprehensive review of the up-to-date fault mode analysis, fault diagnosis signals and algorithms, and fault tolerant control in various dc-dc topologies has been presented. This research will provide a useful design guideline for the reliability improvement in all forms of dc-dc converters.