A Novel Ferroptosis-Related Lncrnas Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

Abstract

BackgroundPapillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs could be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors, and many lncRNAs are related to the pathogenesis of PRCC. However, there are few studies on the ferroptosis-related lncRNAs of PRCC. This study aimed to establish ferroptosis-related lncRNAs prognostic signature in patients with PRCC.MethodsGene expression profile and clinical information of patients with PRCC were obtained from The Cancer Genome Atlas (TCGA) database. Lasso-Penalzed Cox regression and univariate Cox regression analysis were utilized for model construction. The Kaplan-Meier (K-M) and Receiver Operating Characteristic (ROC) curves were plotted to validate the predictive effect of the prognostic signature. Immune cell infiltration and immune function were compared between the high-risk and low-risk groups. Chemotherapy sensitivity analysis was also performed. ResultsWe constructed a prognostic signature consisted of 15 ferroptosis-related lncRNAs. The Kaplan-Meier curves validated the fine predictive accuracy of the prognostic signature (p < 0.001). The area under the curve (AUC) of the lncRNAs signature was 0.930, exhibiting robust prognostic capacity. The high-risk group had a greater degree of immune cell infiltration, such as B cells, T cell CD8, macrophages, NK cell, etc., compared with the low-risk group. There were significant differences in inflammation-promoting, parainflammation and Type I IFN reponse between the low-risk and high-risk groups. The expressions of immune checkpoints including CD80, IDO1, LAG3, etc. were significantly higher in high-risk group. Chemotherapy sensitivity analysis showed that MNX1-AS1, ZFAS1, MIR4435-2HG and ADAMTS9-AS1 were significantly correlated with the sensitivity of some chemotherapy drugs. ConclusionWe demonstrated that a ferroptosis-related lncRNAs prognostic signature could be a novel biomarker for PRCC. Our findings could provide a new insight for immune research and treatment strategies for patients with PRCC.

Pepsinogen/Proton Pump Co‐Expression in Barrett's Esophageal Cells Induces Cancer‐Associated Changes

“…AC022075.1 is a ferroptosis‐related lncRNA downregulated in BAR‐T PGA + ATP4AB cells. Differential expression of AC022075.1 may be associated with overall survival in patients with papillary renal cell carcinoma 67 . We have already demonstrated that MT1G, a protein‐coding ferroptosis gene, is upregulated in BAR‐T PGA + ATP4AB cells.…”